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S.B. Yee, N. Lin, A.Z. Chuang, R.W. Yee; The Efficacy of Autologous Serum in Post-Laser Epithelial Keratectomy (LASEK) Patients . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2636.
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Purpose: To evaluate the efficacy of 20% autologous serum for use as a therapeutic eye drop to reduce haze in laser epithelial keratectomy (LASEK) patients. Methods: This study involved retrospective case studies of LASEK patients at the Hermann Eye Center from 1999-2002. A solution of 20% autologous serum was used as eye drops intra-operatively and post-operatively in 11 patients (21 eyes) undergoing LASEKby a single surgeon (RWY). The autologous serum solution was prepared by obtaining 20 cc of the patient's blood, centrifuging the blood for 4000 rpm/min for 4 minutes, and diluting the serum with balanced salt solution (BSS) to achieve a final concentration of 20%. Eighty five eyes in 52 patients undergoing LASEK did not receive any autologous serum solution. LASEK was performed using a modified Camellin technique with a Alcon Autonomous LADARVision® 4000 Excimer Laser System. Corneal haze was assessed by a single observer (RWY) and was graded from 0 (none) to 4+ (severe with iris features obscured) during a 3-6 month period. Results: The age of patients in the treatment group ranged from 27 to 45 years of age (mean age was 38.2 years ± 5.1) and in the control group ranged from 24 to 67 years of age (mean age was 40.9 years ± 9.6). There were no statistical differences in age range between the treatment and the control groups (P=0.10). There were no statistical differences in mean ablation depth and in ablation depth/corneal thickness ratio (AD/CT) between the treatment and control groups (P=0.07 and 0.08, respectively). A high AD/CT ratio (AD/CT > 0.18) has been associated with an increased risk of haze. Nonetheless, patients who received 20% autologous serum had a lower incidence of post-operative corneal haze (regardless of whether the patient had high or low AD/CT group) during the 3-6 month follow up period. View OriginalDownload SlideView OriginalDownload Slide
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