May 2003
Volume 44, Issue 13
ARVO Annual Meeting Abstract  |   May 2003
Influence of Intraoperative Epithelial Defects on Outcomes in LASIK for Myopia
Author Affiliations & Notes
  • M.S. Oliva
    Ophthalmology, University of Washington, Seattle, WA, United States
  • R. Ambrosio Jr.
    Ophthalmology, University of São Paulo, São Paulo, Brazil
  • S.E. Wilson
    Ophthalmology, University of São Paulo, São Paulo, Brazil
  • Footnotes
    Commercial Relationships  M.S. Oliva, None; R. Ambrosio Jr., None; S.E. Wilson, None.
  • Footnotes
    Support  NIH Grant EY10056 and an Unrestricted Grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 2649. doi:
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    • Get Citation

      M.S. Oliva, R. Ambrosio Jr., S.E. Wilson; Influence of Intraoperative Epithelial Defects on Outcomes in LASIK for Myopia . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2649.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: To evaluate whether intraoperative epithelial defects have an adverse effect on achieving desired refractive outcomes following laser in situ keratomileusis (LASIK) for myopia. Methods: Thirty eyes that had intraoperative epithelial defects on the LASIK flap were compared with sixty randomly-selected control eyes, matched for age, preoperative spherical equivalent (SE), and pre-operative cylinder, that had no intraoperative epithelial defects. Preoperative and postoperative clinical data were compared between the two groups retrospectively with statistical analyses performed using the Students t-test and analysis of means. Comparison variables included preoperative SE, three-month postoperative SE, three-month postoperative best spectacle-corrected visual acuity (BSCVA), attempted correction, amount of undercorrection at three months postoperative, and whether or not LASIK enhancement was performed at three months postoperatively. Results: Eyes with intraoperative epithelial defects showed more undercorrection at three months (p= 0.005), were more likely to have lost lines of BSCVA (p= 0.0004), and underwent more enhancement procedures at 3 months (p= 0.004), in comparison to control eyes. Conclusion: Intraoperative epithelial defects during LASIK predispose eyes to increased wound healing leading to myopic regression, irregular wound healing with loss of BSCVA, and increased need for enhancement procedures.

Keywords: refractive surgery: complications • cornea: epithelium • clinical (human) or epidemiologic studies: out 

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