Purchase this article with an account.
E. Kim, S.E. Jung, R.M. Jun, J.H. Lee, K.Y. Seo, J.B. Lee; Avellino Dystrophy after Laser in situ Keratomileusis . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2672.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: . To report Avellino corneal dystrophy cases that exacerbated after uncomplicated laser in situ keratomileusis (LASIK) for myopia and a case severely exacerbated after mechanical removal of the granular material from the interface after LASIK. Methods: Six patients with recurrent corneal dystrophy showing granular deposits at the interface after LASIK were examined for BIGH3 mutations by PCR sequencing of DNA. One patient of heterozygous Avellino dystrophy exacerbated and previously reported was followed up for 16 months after removal of granular deposit from the interface for the observation of the recurrence of the opacities Results: All patients were confirmed to have heterozygous Avellino dystrophy gene. Best spectacle-corrected visual acuity decreased with the progression of opacities. Avellino dystrophy became severely exacerbated in 6 months after mechanical removal of the granules from the interface. Conclusions: LASIK is contraindicated in patients with Avellino dystrophy because it aggravates corneal lesions of previously mild deposits and induces decrease of the best corrected visual acuity of the patients. Mechanical removal of the material deposited at the interface is not recommended.
This PDF is available to Subscribers Only