May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Assessment of Macular Function by mf-ERG in Patients with Choroidal Neovascularization due to Pathologic Myopia before and after Photodynamic Therapy
Author Affiliations & Notes
  • M. Moschos
    Ophthalmology, Hopital Jules Gonin-Lausanne, Lausanne, Switzerland
  • D. Panayiotidis
    Ophthalmology, University of Athens, Athens, Greece
  • G. Theodosiadis
    Ophthalmology, University of Athens, Athens, Greece
  • E. Synodinos
    Ophthalmology, University of Athens, Athens, Greece
  • E. Georgiadou
    Ophthalmology, University of Athens, Athens, Greece
  • M.N. Moschos
    Ophthalmology, University of Athens, Athens, Greece
  • Footnotes
    Commercial Relationships  M. Moschos, None; D. Panayiotidis, None; G. Theodosiadis, None; E. Synodinos, None; E. Georgiadou, None; M.N. Moschos, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 2697. doi:
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      M. Moschos, D. Panayiotidis, G. Theodosiadis, E. Synodinos, E. Georgiadou, M.N. Moschos; Assessment of Macular Function by mf-ERG in Patients with Choroidal Neovascularization due to Pathologic Myopia before and after Photodynamic Therapy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2697.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Pathologic myopia has been reported to be a major cause of blindness in the United States. Many of these cases of visual loss are the result of the development of choroidal neovascularization (CNV). Photodynamic therapy (PDT) is widely used in order to treat subfoveal CNV due to pathologic myopia.The purpose of this study is to evaluate the macular function by means of mf-ERG before and after PDT in patients with classic subfoveal CNV due to pathologic myopia. Methods: 10 eyes of 10 patients (6 male, 4 female) with classic subfoveal CNV due to pathologic myopia were studied. Pathologic myopia was defined as an eye requiring a distance correction of at least –6.0 diopters (D: spherical equivalent). All patients received Verteporfin therapy. Fluorescein angiography and mf-ERG were performed in each patient 1 day before and 1 week, 3 and 6 months after PDT treatment. Best-corrected visual acuity was measured on a Bailey-Lovie chart using a standardized refraction protocol. For the recording of mf-ERG the VERIS III was used. Results: The mean visual acuity before PDT was 45 (SD 7,318). The mean retinal response density (RRD) before PDT in area 1 was 4.12 nV/deg2 (SD 2.121) and in area 2 1.997 nV/deg2 (SD 1.793). Six months after treatment fluorescein angiography shows no CNV leakage in all cases. The mean visual acuity after PDT was 51.6 (SD 8,302). The mean retinal response density (RRD) after PDT in area 1 was 5.562 nV/deg2 (SD 3.6) and in area 2 2.43 nV/deg2 (SD 2.366). Conclusions: mf-ERG evaluates objectively the macular function of myopic eyes with CNV. After successful PDT, the electrical activity of the foveal and perifoveal area is higher than before treatment. This finding postulates the efficacy of PDT in the treatment of the disease.

Keywords: myopia • photodynamic therapy • photoreceptors 
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