May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Increased Soluble Interleukin-6 Receptor in Vitreous Fluid of Proliferative Vitreoretinopathy
H. Yamamoto; H. Hayashi; H. Uchida; N. Umeda; H. Ozaki; H. Kato; K. Oshima
Author Affiliations & Notes
  • H. Yamamoto
    Dept of Ophthalmology, Fukuoka Univ Sch of Med, Fukuoka, Japan
  • H. Hayashi
    Dept of Ophthalmology, Fukuoka Univ Sch of Med, Fukuoka, Japan
  • H. Uchida
    Dept of Ophthalmology, Fukuoka Univ Sch of Med, Fukuoka, Japan
  • N. Umeda
    Dept of Ophthalmology, Fukuoka Univ Sch of Med, Fukuoka, Japan
  • H. Ozaki
    Dept of Ophthalmology, Fukuoka Univ Sch of Med, Fukuoka, Japan
  • H. Kato
    Dept of Ophthalmology, Fukuoka Univ Sch of Med, Fukuoka, Japan
  • K. Oshima
    Dept of Ophthalmology, Fukuoka Univ Sch of Med, Fukuoka, Japan
  • Footnotes
    Commercial Relationships  H. Yamamoto, None; H. Hayashi, None; H. Uchida, None; N. Umeda, None; H. Ozaki, None; H. Kato, None; K. Oshima, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 2953. doi:
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      H. Yamamoto, H. Hayashi, H. Uchida, N. Umeda, H. Ozaki, H. Kato, K. Oshima; Increased Soluble Interleukin-6 Receptor in Vitreous Fluid of Proliferative Vitreoretinopathy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2953.

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Abstract

Abstract: : Purpose: To clarify the effect of the interaction between interleukin-6 (IL-6) and its soluble receptor (sIL-6R) on retinal pigment epithelial (RPE) cell proliferation in proliferative vitreoretinopathy (PVR). Methods: Concentrations of IL-6 and sIL-6R molecules in vitreous fluids were measured in eyes with PVR and idiopathic macular hole (MH), and the localization of IL-6 and IL-6R on the PVR fibrous membrane was studied. Production of IL-6 and sIL-6R by cultured RPE cells and the effect of the IL-6/sIL-6R complex on growth of cultured RPE cells were analyzed. Results: Positive staining of IL-6 and IL-6R was observed in proliferating membranes in all PVR cases. IL-6 and sIL-6R concentrations in vitreous fluid from eyes with PVR were significantly higher than in eyes with MH (p<0.05). A time-dependent increase in IL-6 molecules was identified in the culture medium of RPE cells, although sIL-6R was not detected. Dose-dependent growth of RPE cells was observed in the three concentrations (50, 100, and 500 ng/ml) of sIL-6R used. Conclusions: IL-6 derived from blood while breakdown of the blood-retinal barrier (BRB) and produced by RPE cells and hematogenous sIL-6R cause RPE proliferation.

Keywords: proliferative vitreoretinopathy • cytokines/chemokines • retinal pigment epithelium 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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