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D. Ochoa-Contreras, R.M. Romero-Castro, J.O. Rivera-Sempértegui, V. Karageozian, h. Karageozian, H. Quiroz-Mercado; Anatomical and Visual Outcome of Retinal Detachment Surgery in Children with Intravitreal Carbamide Previous a Vitrectomy Surgical Procedure . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3001.
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Purpose: . To evaluate the visual and anatomical outcome, as well as the safety profile of carbamide (Visoph) intravitreal injection prior to vitrectomy in the setting of rhegmatogenous retinal detachment in children. Methods: Prospective, longitudinal, experimental, study. Paediatric patients were included with rhegmatogenous retinal detachment that underwent intravitreal injection of Visoph in dose of 3.0mg/50ml., 24 hours before vitrectomy. Results: 6 eyes of 6 patients were studied prospectively with a mean follow up of 2 months (range 1 – 3) and a mean age of 8 years (range 1 – 20 ) whit retinal detachment associated with 2 cases of Stickler syndrome; 3 associated with high myopia and 1 with traumatic subluxation of the lens. Complete re-attachment was achieved in 100% (6/6) of cases after vitrectomy. Silicon oil was used in 4 cases and C3F8 in 2. Significant visual improvement occurred in all patients. No complications were observed. Conclusions: In this small sample of pediatric patients, Visoph appears to facilitate removal of the vitreous. The degree of vitreosyneresysis depends on the Visoph mediated formation of polyelectrolyte complexes with vitreous components. The success rate of vitrectomy, in this difficult patient population, both with regard to visual acuity and anatomic reattachment, was noticeably better with the addition of the intravitreal Visoph
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