May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Hydrogel Tissue Adhesive: Feasiblity Study for Intraocular Use ERG and Histology
Author Affiliations & Notes
  • T. Fukuchi
    Department of Ophthalmology, Schepens Retina Associates, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, United States
  • J. Sueda
    Department of Ophthalmology, Schepens Retina Associates, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, United States
  • N. Usumoto
    Department of Ophthalmology, Schepens Retina Associates, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, United States
  • T. Okuno
    Department of Ophthalmology, Schepens Retina Associates, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, United States
  • D. Kalayci
    Department of Ophthalmology, Schepens Retina Associates, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, United States
  • A. Sawhney
    Confluent Surgical Inc., Waltham, MA, United States
  • T. Hirose
    Confluent Surgical Inc., Waltham, MA, United States
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 3015. doi:
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      T. Fukuchi, J. Sueda, N. Usumoto, T. Okuno, D. Kalayci, A. Sawhney, T. Hirose; Hydrogel Tissue Adhesive: Feasiblity Study for Intraocular Use ERG and Histology . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3015.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: A new hydrogel tissue glue was developed specially for Ophthalmic use. It is composed of two synthetic materials in liquid forms:one polyethylene glycol (PEG) solution almost gel like texture, and the other amine component which is quite liquid. We evaluated this material for possible intraocular usage. Methods: Six New Zealand Albino male rabbits were used. 0.1 cc of this hydrogel was injected into the vitreous and the same amount of BSS in left eyes as control. Biomicroscopy, indirect ophthalmoscopy and fundus photography were performed at frequent intervals until 70 days postoperatively. ERG was recorded on both eyes simultaneously on 90-th days and then both eyes were enucleated for histological evaluation. Results: When both materials are mixed, a slid membrane is formed in 8-10 seconds. It was translucent, flexible, and soft, and had smooth surface. It stayed solid in BSS but dissolved completely with BSS within 7 weeks. No inflammatory reaction but mild posterior lens capsular opacity was observed by slit-lamp biomicroscopy in the 2 eyes in the study group. There was no significant difference in both amplitude and implicit time of a- and b-waves of the ERG in all stimulus intensity levels. The one of the oscillatory potentials tend to show prolonged peak times in the study group. No significant histological abnormality was detected in either groups Conclusions: This hydrogel glue used in this study showed no significant toxic effect to the eye. It can easily be delivered into the vitreous and warrants further study for possible means of patching the retinal break.

Keywords: retinal detachment • animal model • electroretinography: non-clinical 
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