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H. Rashed, M.P. Czajka, B.W. McCuen, C.A. Toth, T. Cummings, H. Nguyen, S. Fekrat; Radial Optic Neurotomy in the Porcine Eye Without Retinal Vein Occlusion . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3056.
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Purpose: To demonstrate the histopathologic changes on the optic nerve and its vasculature in the porcine eye following radial optic neurotomy. Methods: Radial optic neurotomy was performed in normal eyes of xxxx Yorkshire Cross pigs. A radial incision at the edge of the nasal optic nerve head was made using a 20 gauge MVR blade while the intraocular pressure was elevated. Surgery was concluded when hemostasis was achieved. Weekly fundus examinations were performed. Group I eyes were enucleated on the day of surgery for histological examination. Group II eyes were enucleated 1 week postoperatively and Group III eyes were enucleated 3 weeks postoperatively. Results: Ophthalmoscopic examination demonstrated engorged blood vessels at the neurotomy site up to 3 weeks after surgery with minimal or no hemorrhage. Histological examination in Group I eyes demonstrated traumatic incision in the optic nerve with focal hemorrhage and edema along the incision tract. Part of the sclera and retina were entrapped in the neurotomy site. There was no much difference between the 1 week and 3 week examinations. These histological sections showed a traumatic incision site with fibroblast and astrocyte proliferation. Focal hemorrhage and edema were still present although at 3 weeks, the red blood cells were extravasated. Part of the entrapped sclera and retina were present in the lesion. Conclusions: Following radial optic neurotomy, florid gliosis occurs at the neurotomy site. Although bleeding was rare intraoperatively, histological sections showed hemorrhage and edema in the optic nerve at the neurotomy site.
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