May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
The Impact of Cytomegalovirus Retinitis on the Quality of Life of Patients with the Acquired Immune Deficiency Syndrome
Author Affiliations & Notes
  • J.H. Kempen
    Ophthalmology, Epidemiology, Johns Hopkins University, Baltimore, MD, United States
  • B.K. Martin
    Epidemiology, Johns Hopkins University, Baltimore, MD, United States
  • A.W. Wu
    Health Policy & Management, Medicine, Epidemiology, Johns Hopkins University, Baltimore, MD, United States
  • B. Barron
    Ophthalmology, Louisiana State University, New Orleans, LA, United States
  • J.E. Thorne
    Ophthalmology, Johns Hopkins University, Baltimore, MD, United States
  • D.A. Jabs
    Ophthalmology, Medicine, Epidemiology, Johns Hopkins University, Baltimore, MD, United States
  • Studies of Ocular Complications of AIDS Rsch Group
    Ophthalmology, Medicine, Epidemiology, Johns Hopkins University, Baltimore, MD, United States
  • Footnotes
    Commercial Relationships  J.H. Kempen, None; B.K. Martin, None; A.W. Wu, None; B. Barron, None; J.E. Thorne, None; D.A. Jabs, None.
  • Footnotes
    Support  NIH Cooperative Agreements U10 EY08052, U10 EY08057, U10 EY08067
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 3127. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J.H. Kempen, B.K. Martin, A.W. Wu, B. Barron, J.E. Thorne, D.A. Jabs, Studies of Ocular Complications of AIDS Rsch Group; The Impact of Cytomegalovirus Retinitis on the Quality of Life of Patients with the Acquired Immune Deficiency Syndrome . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3127.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: To determine the impact of cytomegalovirus (CMV) retinitis on the quality of life (QOL) of patients with the Acquired Immune Deficiency Syndrome (AIDS). Methods: Nine hundred seventy-one patients with AIDS were enrolled at 19 centers throughout the United States: 212 (22%) with longstanding CMV retinitis, 50 (5%) with newly diagnosed CMV retinitis, and 709 (73%) without CMV retinitis. Vision-related QOL was assessed using the Studies of Ocular Complications of AIDS instrument, designed for patients with CMV retinitis. General health-related QOL was measured using a modification of the Medical Outcomes Survey-HIV instrument. Health utility measurements were taken using the EuroQol EQ-5D and thermometer techniques. Cytomegalovirus retinitis status was determined ophthalmoscopically, by a certified ophthalmologist. Results: Vision-related QOL scores were substantially lower among patients with CMV retinitis than those without CMV retinitis, but results were similar among patients with newly diagnosed and longstanding CMV retinitis. For most general health-related QOL domains and health utility measures, the longstanding CMV retinitis group and the group without CMV retinitis had similar results, whereas the newly diagnosed CMV retinitis group scored substantially worse on most of these scales. In multiple regression analysis of representative scale scores, most observed differences in general health-related QOL and health utility were attenuated by adjusting for differences in demographic characteristics, CD4+ T cell count, HIV viral load, and current use of highly active antiretroviral therapy (HAART). However, the association of CMV retinitis with lower vision-related QOL was independent of differences in these characteristics. Conclusions: In the era of HAART, CMV retinitis is associated with substantially lower vision-related quality of life, even among patients with longstanding disease who otherwise have general health-related QOL and health utility similar to that of patients never diagnosed with CMV retinitis.

Keywords: AIDS/HIV • cytomegalovirus • quality of life 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×