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M. Liu, A. Martidis, D. Roth, J. Belmont, M. Nelson, J. Chieh, A. Sivalingam, C. Regillo, J. Federman; Complications of Intravitreal Triamcinolone Acetonide . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3222.
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Purpose: To describe the incidence of complications related to the use of intravitreal triamcinolone acetonide (IVT) for the treatment of macular edema of various etiologies. Methods: Records of 387 patients treated with IVT were analyzed retrospectively. Results: Three hundred and eighty seven eyes of 368 patients were treated with 4mg of IVT. Mean follow-up was 6.1 months. The mean pre-operative intraocular pressure (IOP) was 15.3 (+/-2.8) mmHg. The mean IOP at 1, 3, and 6 months postoperatively were 17.1 (+/- 3.4), 17.9 (+/-3.7), and 16.8 (+/-3.9) mmHg, respectively. Three eyes (0.8%) underwent guarded filtration procedures for steroid response. Sixty-three eyes (16.3%) had IOP above 21 mmHg and 20 (5.2%) eyes had IOP above 30 mmHg during the post-operative period. Ten eyes (2.6%) developed culture-negative endophthalmitis, and 2 eyes (0.5%) developed culture-proven endophthalmitis (S. epidermidis). Seven eyes (1.8%) had documented progression of cataract. One eye (0.3%)required laser peripheral iridotomy immediately after injection due to angle closure, and one eye (0.3%) developed herpes simplex keratitis 2 months after the injection of triamcinolone. Conclusions: The complications of IVT include raised IOP, culture-negative pseudoendophthalmitis, endophthalmitis, and progression of cataract. Further follow-up is needed to evaluate the long-term safety of IVT.
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