A New OCT 3 Macula Map for Detection of Glaucoma

Abstract

Abstract: : Purpose: Previous studies already observed retinal thinning in the macular region of eyes with glaucoma. We evaluated the ability of a new OCT-3 macula map to differentiate between normal and glaucomatous eyes. Methods: Patients underwent automated perimetry (Humphrey 24-2 SITA-standard) and OCT-3 scanning (software version A1.1, Carl Zeiss Meditec, Inc., Dublin, CA). 7 vertical line scans (each with 512 A scans) of 6mm length, 1mm apart, were performed in the macula (figure) of 34 eyes of 34 glaucoma patients (HVF mean MD -5.3 ± 4.8 dB; mean PSD value, 6.6 ± 4.3d B) and 15 eyes of 15 healthy control subjects. Using specialized software, superior and inferior mean retinal thickness measurement and a superior/inferior mean retinal thickness ratio (RTR) were calculated for each line scan of each patient. Area under the ROC curve, sensitivity and specificity of all these parameters for discriminating between glaucomatous and healthy eyes were also calculated. Results: Superior and inferior mean retinal thickness of each of the 7 vertical scans were significantly different between glaucomatous and healthy eyes (p<0.05). Area under the ROC curve for these parameters varied from 0.73(N3 inferior) to 0.88(T1 superior). RTR values of all vertical scans varied from 0.92 to 1.1 for normal patients and 0.73 to 1.18 for glaucoma patients. 76.5% of the glaucoma patients had at least one RTR outside the control group range. Using an arbitrary range of 0.92-1.07 as normal, the sensitivity and specificity of any RTR outside this range were respectively 82.35 % and 86.67%. Conclusions: Parameters obtained with the new macular thickness map were able to differentiate between healthy controls and glaucomatous patients.  

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, S • macula/fovea • imaging/image analysis: clinical