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C.A. Girkin, M. Gerald, D. Julio; Racial Differences in the Association Between Optic Disc Topography and Glaucoma . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3368.
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Purpose:To determine the structural characteristics of the optic disc that are associated with glaucoma in African-Americans and Caucasians and whether these characteristics differ between these races Methods:Parameters of optic disc topography from 233 African-American eyes and 172 Caucasian eyes were included in the analysis. 79 African-American eyes and 93 Caucasian eyes from normal subjects were used as a control group. Logistic regression was used to calculate the association between glaucoma, defined by the visual field, and topographic parameters obtained using confocal scanning laser ophthalmoscopy using odds ratios at binary cutpoints. The cup, rim and disc margin parameters identified as being independently associated with glaucoma in these reduced models were then included in a single multivariable model. In the context of this model, only those variables that retained their statistical significance were maintained in the final model. This approach was employed for the total study populations, and then separately for African-Americans, and Caucasians. Results:There were no significant differences in age, gender, highest measured intraocular pressure, or mean defect in the visual field between African-American and Caucasian among the normal control subjects or the glaucoma patients. Rim-to-disc ratio (2.20, 95% CI: 1.20-4.02), cup shape (1.87, 95% CI: 1.04-3.33) were independent predictors of glaucoma in the Caucasian group, whereas only rim area was independently predictive of glaucomatous field loss in African Americans (1.65, 95% CI: 1.01-2.67) Conclusions:Structural characteristics of the optic disc that are best predictive of glaucoma differ significantly between African-Americans and Caucasians.
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