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P. Joson, R. Gurses-Ozden, R.M. Vessani, M. Makornwattana, S. Zafar, J.M. Liebmann, C. Tello, R. Ritch; Optical Coherence Tomography (OCT-3) Shows Retinal Nerve Fiber Layer Injury Earlier Than Achromatic Automated Perimetry . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3392.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To compare macular retinal and peripapillary retinal nerve fiber layer (RNFL) thickness measurements between normal and glaucoma suspect eyes. Methods: A glaucoma suspect eye was defined as an eye with a normal achromatic field in a patient with bilateral glaucomatous optic neuropathy and unilateral achromatic field loss. Glaucoma suspect eyes and normal eyes were scanned using fast RNFL and macula protocols (OCT-3 software version A1.1, Carl Zeiss Meditec, Inc., Dublin, CA). Macular and RNFL thickness measurements in these groups were compared. Results: Thirteen glaucoma suspect eyes (13 patients) and 16 normal eyes (16 subjects) were enrolled. Normal subjects were younger than the glaucoma patients (39.4 ± 16.6 vs. 55.6 ± 11.2, p=0.004, t-Test). MD and PSD parameters were similar between normal and glaucoma suspect eyes (-0.84 vs. -1.07 and 1.57 vs. 1.71, p=0.66 and p=0.49; respectively). Total mean, and superior mean RNFL thickness was thinner in the glaucoma suspect eyes (mean differences, 16.8 and 32.1 µm; respectively, p=0.007 for both comparisons). Mean total macular volume was less and mean macular retinal thickness in the superior inner, superior outer and temporal outer macular quadrants (6 mm circle diameter) was thinner in the glaucoma suspect eyes (mean differences, 0.34 mm3, 14.5, 14.9, 16.7 µm, p=0.02, p=0.04, p=0.003, p=0.004; respectively). Conclusions: OCT-3 may detect change in macular retinal thickness and peripapillary RNFL thickness measurements before any change is detected in the achromatic visual field.
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