May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Determinants of Intraocular Pressure and its Association with Glaucomatous Optic Neuropathy in Chinese Singaporeans: The Tanjong Pagar Survey
Author Affiliations & Notes
  • P.J. Foster
    Epidemiology, Institute of Ophthalmology, London, United Kingdom
  • D. Machin
    Clinical Trials & Epidemiological Sciences, National Cancer Centre, Singapore, Singapore, Singapore
  • T. Wong
    Ophthalmology, National University Hospital, Singapore, Singapore
  • J.F. Kirwan
    Ophthalmology, National University Hospital, Singapore, Singapore
  • P.T. Khaw
    Pathology & Wound Healing Studies, Institute of Ophthalmology, London, United Kingdom
  • S.K. Seah
    Glaucoma, National Eye Centre, Singapore, Singapore
  • Footnotes
    Commercial Relationships  P.J. Foster, None; D. Machin, None; T. Wong, None; J.F. Kirwan, None; P.T. Khaw, None; S.K.L. Seah, None.
  • Footnotes
    Support  NMRC-SERI- 1997
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 3410. doi:
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      P.J. Foster, D. Machin, T. Wong, J.F. Kirwan, P.T. Khaw, S.K. Seah; Determinants of Intraocular Pressure and its Association with Glaucomatous Optic Neuropathy in Chinese Singaporeans: The Tanjong Pagar Survey . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3410.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To describe the relationship between intraocular pressure (IOP) and various anthropomorphic, demographic, socio-economic, systemic and ocular factors. Methods: IOP was estimated using Goldmann applanation tonometry. The drainage angle was assessed using static and dynamic gonioscopy in low-light conditions, to grade width of the drainage angle, and identify areas of peripheral anterior synechiae (PAS). The optic nerve was examined at high magnification through a dilated pupil using a fundus contact lens. Static automated (Humphrey) visual field testing was carried out on subjects suspect of having glaucoma. Glaucoma was diagnosed on the basis of structural and functional abnormalities of the optic nerve. Multiple linear and logistic regression were used to test association between risk factors and IOP or glaucoma. Results: Higher systolic blood pressure (P< 0.001), more quadrants of PAS (P= 0.02) and narrower width of drainage angle (P= 0.049) and greater corneal thickness were the only significant, independent determinants of higher IOP. A 100 µm increase in corneal thickness was associated with an increase in mean IOP of 1.5 to 1.8 mm Hg (P< 0.001). No other significant associated factors were identified. Odds of GON increased 1.2 times per mm Hg rise in screening IOP. Conclusions: IOP estimates vary with systolic blood pressure and corneal thickness, the latter probably as a source of measurement error. Variation in IOP with angle width may suggest that trabecular compaction significantly contribute to causes of IOP increase independent of angle-closure. Glaucoma is an IOP-related phenomenon among Chinese Singaporeans.

Keywords: clinical (human) or epidemiologic studies: ris • intraocular pressure • clinical (human) or epidemiologic studies: pre 
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