May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Effect of Ibopamine on Aqueous Humor Flow in Normal Human Eyes
Author Affiliations & Notes
  • R.F. Brubaker
    Ophthalmology, Mayo Clinic, Rochester, MN, United States
  • J. McLaren
    Ophthalmology, Mayo Clinic, Rochester, MN, United States
  • D. Herman
    Ophthalmology, Mayo Clinic, Rochester, MN, United States
  • C. Nau
    Ophthalmology, Mayo Clinic, Rochester, MN, United States
  • L. Wayman
    Ophthalmology, Mayo Clinic, Rochester, MN, United States
  • P. Dionisio
    Angelini Pharmaceuticals, ACRAF SpA, Rome, Italy
  • M.G. Ciarniello
    Angelini Pharmaceuticals, ACRAF SpA, Rome, Italy
  • M.T. Rosignoli
    Angelini Pharmaceuticals, ACRAF SpA, Rome, Italy
  • Footnotes
    Commercial Relationships  R.F. Brubaker, Angelini Pharmaceuticals F; J. McLaren, Angelini Pharmaceuticals F; D. Herman, Angelini Pharmaceuticals F; C. Nau, None; L. Wayman, None; P. Dionisio, Angelini Pharmaceuticals E; M.G. Ciarniello, Angelini Pharmaceuticals E; M.T. Rosignoli, Angelini Pharmaceuticals E.
  • Footnotes
    Support  NIH Grant 00634
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 3432. doi:
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      R.F. Brubaker, J. McLaren, D. Herman, C. Nau, L. Wayman, P. Dionisio, M.G. Ciarniello, M.T. Rosignoli; Effect of Ibopamine on Aqueous Humor Flow in Normal Human Eyes . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3432.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Ibopamine is a prodrug of epinine (deoxyepinephrine) that exhibits activity at dopaminergic and adrenergic receptors. It has been shown to cause mydriasis without cycloplegia (1) and to increase the rate of aqueous humor flow in normotensive human eyes. It is known that mydriasis can interfere with the measurement of aqueous flow. For this reason a study was undertaken to remeasure ibopamine’s effect under conditions where mydriasis was controlled. Methods: Twenty-four healthy blue-eyed Caucasian subjects were studied in a randomized, double-masked, paired-comparison, crossover study. Tropicamide was used as a positive mydriatic control and dapiprazole was used as a mydriatic antagonist. Aqueous flow was calculated from the rate of disappearance of topically applied fluorescein. Results: When ibopamine was given alone, the calculated rate of aqueous flow peaked at 7.77 ± 1.02 µl/min (mean ± SE) compared to a rate of 2.82 + 0.11 µl/min when placebo was given, an increase of 176%. When the mydriatic effect of ibopamine was blocked with dapiprazole, the calculated rate of aqueous flow was 3.09 ± 0.09 µl/min compared to a tropicamide-dapiprazol control rate of 2.74 ± 0.09 µl/min, an increase of 13% (p<0.001). Conclusions: We interpreted the very large increase in the rate of clearance of fluorescein in the ibopamine treated eye to be due mainly to loss of fluorescein to the posterior chamber through the uncyclopleged, dilated pupil. We interpreted the 13% increase in clearance of fluorescein in the ibopamine-dapiprazole treated eye to be a real effect of ibopamine on the rate of aqueous humor flow. Ibopamine appears to be among a small group of drugs that stimulate the rate of aqueous humor flow. (1)Virno M, Taverniti L, Motolese E, Taloni M, Bruni P, Pecori Giraldi J. Ibopamina: nuovo midriatico non cicloplegico (nota preliminare). Boll Ocul 1986; 65(11,12): 1135-46

Keywords: aqueous • inflow/ciliary body • pharmacology 
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