May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
The Association of Clusterin With Ischemic Damage in Oxygen Induced Retinopathy
J. Jung; Y. Kim; Y. Chung; J. Kim; Y.S. Yu
Author Affiliations & Notes
  • J. Jung
    Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Y. Kim
    Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Y. Chung
    Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • J. Kim
    Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Y.S. Yu
    Department of Ophthalmology, Seoul National University College of Medicine & Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  J. Jung, None; Y. Kim, None; Y. Chung, None; J. Kim, None; Y.S. Yu, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 3568. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      The Association of Clusterin With Ischemic Damage in Oxygen Induced Retinopathy
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      J. Jung, Y. Kim, Y. Chung, J. Kim, Y.S. Yu; The Association of Clusterin With Ischemic Damage in Oxygen Induced Retinopathy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3568.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Abstract: : Purpose: To determine whether clusterin is associated with ischemic damage in oxygen induced retinopathy Methods: 7-day-old C57BL mice were kept under hyperoxic condition (75-80 % oxygen) at 23°C for 5 days. Pups were returned to normal condition at postnatal day (P) 12. At P12, 14, 18, 26, pups were sacrifice. Immunohistochemistry and Western blotting for flt-1/flk-1 and clusterin were performed. The extent of angiogenesis was measured with time sequence. Results: The immunoreactivity of clusterin was prominent in inner retina, where flt-1/flk-1 was expressed, and was temporally associated with flt-1/flk-1 expression. The quantitative change of clusterin was proportional to that of angiogenesis. Conclusions: Clusterin is expressed in association with retinal ischemic damage. It may play a role in retinal angiogenesis.

Keywords: retinal development • oxidation/oxidative or free radical damage • immunohistochemistry 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept