Abstract
Abstract: :
Purpose: To analyze OCT features in French patients affected by RP. The retinal thickness is evaluated as a new clinic data for the phenotype-genotype correlation. Methods: A complete ophthalmologic examination was performed in RP patients, including personal and familial history, best corrected visual acuity, fundus examination, visual field, ERG and OCT. A total of 19 RP patients (35 eyes), 4 cone-rod dystrophy patients (7 eyes) were analyzed. The retinal thickness beyond the central circle (500 µm diameter) was measured and the region of weak back-scattering corresponding to photoreceptors was classified as normal, reduced or absent. Results: A wide range of variation in retinal thickness was observed in these eyes (155.83 to 282.17 µm, mean: 211.32, SD: 33.22 µm). No statistical correlation could be found between retinal thickness and duration of symptoms, mode of inheritance, age of onset, or severity of the disease (i.e. best corrected visual acuity worse then 20/200 at the age of 30 years old). Retinal thickness was significantly (p < 0,05) reduced when the photoreceptor layer was reduced or absent. In addition, OCT authentified associated macular edema or atrophy. Discussion: A large variation of thickness could be measured in these RP patients , but no clinical correlation could be established. This is consistent with the genetic, molecular and clinic heterogeneity of the disease. OCT may be taken into consideration in RP evaluation for future studies, and could be used as a clinical tool to assess progression, in comparison with visual field and ERG progression.
Keywords: retinitis • clinical (human) or epidemiologic studies: sys • imaging methods (CT, FA, ICG, MRI, OCT, RTA, S