May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Optical Coherent Tomography for in vivo High Resolution Quantitative Imaging of the Corneal Function
Author Affiliations & Notes
  • K. Hosseini
    Ophthalmology, Univ TX Med Branch-Galveston, Galveston, TX, United States
  • A.I. Kholodnykh
    Center for Biomedical Engineering, Univ TX Med Branch-Galveston, Galveston, TX, United States
  • I.Y. Petrova
    Center for Biomedical Engineering, Univ TX Med Branch-Galveston, Galveston, TX, United States
  • R.O. Esenaliev
    Center for Biomedical Engineering, Univ TX Med Branch-Galveston, Galveston, TX, United States
  • F. Hendrikse
    Ophthalmology, University Eye Clinic, Maastricht, Netherlands
  • M. Motamedi
    Ophthalmology, University Eye Clinic, Maastricht, Netherlands
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 3667. doi:
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      K. Hosseini, A.I. Kholodnykh, I.Y. Petrova, R.O. Esenaliev, F. Hendrikse, M. Motamedi; Optical Coherent Tomography for in vivo High Resolution Quantitative Imaging of the Corneal Function . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3667.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To evaluate the feasibility of optical coherent tomography (OCT) in studying the corneal physiology. Methods: Rabbit cornea dehydration was induced in vivo using either Ophthalgan or simple surface evaporation at room temperature. OCT signals were used to monitor the change in thickness and the optical scattering of the cornea during de- and rehydration processes of the cornea. Results: An accurate measurement of the cornea thickness and scattering was realized while an overshoot was detected during the rehydration process of the cornea. A direct relationship was found between the amount of light backscattering of the cornea and its actual level of hydration. Conclusions: OCT has the potential to be a noninvasive tool for accurate high resolution measurement of corneal hydration.

Keywords: cornea: basic science • optical properties • cornea: clinical science 
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