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C.S. Siganos, E.V. Christodoulakis, V.P. Kozobolis, A.N. Khoury; Intra-operative Use of Mitomycin-C in Ocular Surface Epithelial Neoplasia Excision Prevents Recurrence. Histological Evidence and Long-term Follow-up . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3722.
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Purpose:To present histological evidence on the efficacy of intraoperative Mitomycin-C use in excision of ocular surface epithelial neoplasia for recurrence prevention. Methods: Eight patients (9 eyes), 4 males and 4 females, 56 to 87 years old, with conjunctival neoplasia, were operated during the period between October 1998 and May 2002. Excision of the lesion was combined with intra-operative application of Mitomycin-C 0.02% for 5 minutes. In 5 out of 9 cases, secondary biopsy was performed at least 28 months after surgery, from the area where the lesions were excised. Results: The follow-up period after excision ranged from 6 to 43 months (mean: 30.4 months). Histopathology revealed 4 cases with squamous cell carcinoma (SCC), one with carcinoma in situ, 3 with dysplasia and one case with actinic keratosis. Out of the 9 eyes, only one eye with SCC showed mild clinical recurrence that was successfully treated with one course of topical Mitomycin-C. Up to the last follow-up of this case (36 months), the lesion did not recur. The histological evidence of secondary biopsy performed in 5 eyes at a mean of 32.4 months after excision showed no recurrence. Conclusions: Clinical and histological evidence indicates that intraoperative use of Mitomycin-C in ocular surface epithelial neoplasia excision is a promising approach for recurrence prevention. More cases are needed to establish the efficacy of such an approach. View OriginalDownload SlideView OriginalDownload Slide
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