May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Human Annexin A5 Promotes the Migration of Rabbit Corneal Epithelial Cells
M. Watanabe; W. Yano; S. Kondo; A. Ohhira; Y. Hattori; T. Nishida
Author Affiliations & Notes
  • M. Watanabe
    Tokyo New Drug Lab, Kowa Company Ltd, Tokyo, Japan
  • W. Yano
    Tokyo New Drug Lab, Kowa Company Ltd, Tokyo, Japan
  • S. Kondo
    Tokyo New Drug Lab, Kowa Company Ltd, Tokyo, Japan
  • A. Ohhira
    Tokyo New Drug Lab, Kowa Company Ltd, Tokyo, Japan
  • Y. Hattori
    Tokyo New Drug Lab, Kowa Company Ltd, Tokyo, Japan
  • T. Nishida
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Yamaguchi, Japan
  • Footnotes
    Commercial Relationships  M. Watanabe, Kowa Company Ltd E; W. Yano, Kowa Company Ltd E; S. Kondo, Kowa Company Ltd E; A. Ohhira, Kowa Company Ltd E; Y. Hattori, Kowa Company Ltd E; T. Nishida, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 3823. doi:
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      M. Watanabe, W. Yano, S. Kondo, A. Ohhira, Y. Hattori, T. Nishida; Human Annexin A5 Promotes the Migration of Rabbit Corneal Epithelial Cells . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3823.

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Abstract

Abstract: : Purpose: To investigate the effects of annexin A5, a calcium-dependent phospholipid binding protein, on the rabbit corneal epithelial wound healing in vitro and in vivo. Methods:In vitro study, confluent monolayers of primary cultured rabbit corneal epithelial cells were wounded with a scraper and subsequently cultured in the presence of recombinant human annexin A5. The distance of cell migration into the denuded area was measured after 24 hours. In vivo corneal wound closure model, corneal epithelium was removed by iodine vapor in rabbit. Human annexin A5 eye drops were administered, and the size of the epithelial defect was measured. The wound healing rate was calculated by linear regression analysis. Results:Human annexin A5 promotes the migration of rabbit corneal epithelial cells in vitro. In vivo corneal wound closure model, the wound healing rate of eyes administered with human annexin A5 was significantly higher than the rate of control eye administered with phosphated buffered saline. Conclusions:These results suggested that human annexin A5 promotes corneal wound healing.

Keywords: wound healing • cornea: epithelium • cornea: basic science 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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