May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Association of TNF-alpha Serum Levels with Status of Diabetic Retinopathy and Other Clinical Complications of Diabetes
M.P. Karavellas; E. Papadoyiannis; G. Georgas; C. Tsatsanis; M. Tsilimbaris; D. Skondras; A. Marioris; I. Pallikaris; S. Papavasiliou
Author Affiliations & Notes
  • M.P. Karavellas
    Medical School, University of Crete, Crete, Greece
  • E. Papadoyiannis
    Medical School, University of Crete, Crete, Greece
  • G. Georgas
    Medical School, University of Crete, Crete, Greece
  • C. Tsatsanis
    Medical School, University of Crete, Crete, Greece
  • M. Tsilimbaris
    Medical School, University of Crete, Crete, Greece
  • D. Skondras
    Medical School, University of Crete, Crete, Greece
  • A. Marioris
    Medical School, University of Crete, Crete, Greece
  • I. Pallikaris
    Medical School, University of Crete, Crete, Greece
  • S. Papavasiliou
    Medical School, University of Crete, Crete, Greece
  • Footnotes
    Commercial Relationships  M.P. Karavellas, None; E. Papadoyiannis, None; G. Georgas, None; C. Tsatsanis, None; M. Tsilimbaris, None; D. Skondras, None; A. Marioris, None; I. Pallikaris, None; S. Papavasiliou, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 3984. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Association of TNF-alpha Serum Levels with Status of Diabetic Retinopathy and Other Clinical Complications of Diabetes
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      M.P. Karavellas, E. Papadoyiannis, G. Georgas, C. Tsatsanis, M. Tsilimbaris, D. Skondras, A. Marioris, I. Pallikaris, S. Papavasiliou; Association of TNF-alpha Serum Levels with Status of Diabetic Retinopathy and Other Clinical Complications of Diabetes . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3984.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Abstract: : Purpose: To investigate the relationship between circulating levels of TNF-alpha and the status of diabetic retinopathy, glycemic control, macrovasculopathy and neuropathy in diabetic patients.Methods:Serum levels of TNF-alpha and HbA1c were measured in 51 patients with diabetic retinopathy, 13 diabetic patients without retinopathy, and in a control group of 16 non-diabetic patients.Diabetic retinopathy was assessed by fundoscopy and fluorescein angiography. Macrovasculopathy and neuropathy were assessed clinically and with laboratory investigations. Results:Patients with diabetes had significantly higher levels of circulating TNF-alpha compared with non-diabetic patients (p=0.01). Among diabetic patients the presence of diabetic retinopathy was associated with statistically significantly higher levels of TNF-alpha (p=0.009), while the presence of CSME and a history of PRP did not significantly affect TNF-alpha levels (p=0.43,p=0.07 respectively).Systemic hypertension(p=0.27), macrovasculopathy(p=0.39)and neuropathy(p=0.09)were not associated with higher TNF-alpha levels. Status of glycemic control (HbA1c>7.5, p=0.44)did not affect TNF-alpha levels among diabetic patients. Independent of diabetes status patients older than 65 years of age tended to have higher levels of TNF-alpha compared with younger patients (p=0.019).Conclusion: Diabetic retinopathy is associated with increased levels of TNF-alpha in diabetic patients. Other clinical complications of diabetes do not show a similar association.TNF-alpha may play a role in the pathogenesis of diabetic retinopathy..

Keywords: diabetic retinopathy • inflammation • retina 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept