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M. Sanchez-Salorio, C. Capeans, V. De-Rojas, J. Rodríguez; Levels of Pentosidine in the Vitreous of Eyes with Proliferative Diabetic Retinopathy, Proliferative Vitreoretinopathy and Retinal Detachment . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3995.
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Purpose:To determine the levels of the glycoxidation product pentosidine in the vitreous samples from eyes with proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR), and retinal detachment (RD). Methods:Seventy-three vitreous samples were collected from eyes undergoing vitrectomy for PDR (n=33), PVR (n=28) and RD (n=12). Eighteen samples from cadaveric control eyes were also included in the study. Modified Bradford's method was used to assay protein content and vitreous levels of pentosidine were determined by high performance liquid chromatography. Statistical analyses were performed using Mann-Whitney test. Results:The levels of pentosidine (mean ± standard deviation; pmol of pentosidine/mg of protein) in the cases of PDR were 1,06 ± 1,03 pmol/mg; in the cases of PVR were 1,15 ± 0,88 pmol/mg and in the cases of RD 0,67 ± 0,83 pmol/mg. In the cadaveric control eyes levels were 0,97 ± 0,55 pmol/mg. The levels of pentosidine of the four groups did not differ significantly. Conclusions: The levels of the glycoxidation product pentosidine in the vitreous of eyes with PDR were not significantly different from the levels in the vitreous of eyes with PVR, RD or cadaveric control eyes.
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