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W.E. Jackson, S.A. Hassan, M. Rewers; Laser Retinal Blood Flow Measurements in Patients with Type 1 Diabetes and Controls . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3997.
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Purpose: To evaluate retinal arteriolar diameter, flow velocity and volume in a representative group of young type 1 diabetic patients and controls of comparable age. Techniques: Type 1 diabetic patients (N=23, age15-35) attending the Barbara Davis Center for Childhood Diabetes as well as non-diabetic controls (N=7, age 20-25) were studied. Diabetics had none or mild non-proliferative diabetic retinopathy (modified Airlie House classification grade 1-3). Retinal Doppler velocimetry was performed using the Canon Laser Blood Flowmeter Model 100. A measuring laser beam was locked onto the target arteriole (usually in the upper temporal arcade). A helium-neon laser was used to measure the vessel diameter (in µm). At the same time, a diode laser with a bidirectional pick-up was used to dynamically determine the retinal arterial blood velocity (in mm/s). Blood flow was automatically calculated as the product of velocity and cross-sectional area of the vessel divided by two (to correct for Poiseuille flow). Results: The retinal measurements (mean ± SD) in younger (<25) and older diabetics (>25) as well as controls of comparable age were compared in Table below: In this preliminary data set, there was a suggestion of a decreased flow velocity and increased vessel diameter with type 1 diabetes, however, the retinal blood flow volume did not differ by the study group. Conclusions: Retinal arteriolar diameter, flow velocity and volume can be measured using this minimally invasive and fast (15 min) approach. The predictive value of these parameters as early markers of disease process leading to diabetic retinopathy remains to be established in a larger prospective cohort study. View OriginalDownload SlideView OriginalDownload Slide
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