May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Baseline Hemodynamics and Retinal Thicknessof Diabetic Patients at Risk for the Development of Treatable Diabetic Macular Edema (DME)
K. Guan; C. Hudson; W.C. Lam; M. Mandelcorn; R.G. Devenyi; P.T. Harvey; M. Rawji; T. Wong; R. Nrusimhadevara; J.G. Flanagan
Author Affiliations & Notes
  • K. Guan
    Dept Ophthalmology and Vision Science, Toronto Western Hospital, Toronto, ON, Canada
  • C. Hudson
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • W.C. Lam
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • M. Mandelcorn
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • R.G. Devenyi
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • P.T. Harvey
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • M. Rawji
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • T. Wong
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • R. Nrusimhadevara
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • J.G. Flanagan
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • Footnotes
    Commercial Relationships  K. Guan, None; C. Hudson, None; W.C. Lam, None; M. Mandelcorn, None; R.G. Devenyi, None; P.T. Harvey, None; M. Rawji, None; T. Wong, None; R. Nrusimhadevara, None; J.G. Flanagan, Heidelberg Egineering GmBh C, R.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4018. doi:
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      K. Guan, C. Hudson, W.C. Lam, M. Mandelcorn, R.G. Devenyi, P.T. Harvey, M. Rawji, T. Wong, R. Nrusimhadevara, J.G. Flanagan; Baseline Hemodynamics and Retinal Thicknessof Diabetic Patients at Risk for the Development of Treatable Diabetic Macular Edema (DME) . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4018.

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Abstract

Abstract: : Purpose: To define the sample characteristics at baseline of patients with diabetes stratified by grade of retinopathy, including patients at particular risk for the development of sight-threatening DME. Methods: Group 1: 47 subjects without retinopathy. Group 2: 45 subjects with micro-aneurysms and / or hard exudates within 2 disc diameters of the fovea. Group 3: 31 subjects with pre-treatable macular edema. LogMAR visual acuity (VA) and LOCS III assessment was undertaken at each visit. Retinal hemodynamics (diameter, velocity and flow) were assessed in a superior retinal arteriole using the Canon Laser Blood Flowmeter (CLBF), model 100. Foveal average (FAV) thickness within a 600 µm radius circle and perifoveal average thickness (PFAV) within a 2500 µm radius annulus was measured using the Retinal Thickness Analyzer (RTA). An index of edema was also measured for a 500 um circle and a full field annulus using the Macular Edema Module (MEM) of the Heidelberg Retina Tomograph II (HRTII). All measures were compared between groups using a student's t-test with an α=0.05. Results: There was a significant difference in logMAR VA between groups 1 and 2 (mean -0.08 vs -0.03 respectively, p=0.03). The LOCS III assessment showed a significant difference in nuclear opalescence, cortical cataracts and posterior subcapsular cataract between groups 1 and 3 (mean 2.07 vs 2.41, p=0.04; 0.46 vs 1.07, p=0.004; 0.18 vs 0.40, p=0.004 respectively). No significant difference was found between groups for retinal diameter and blood velocity using the CLBF. The difference between groups 1 and 3 approached significance for blood flow (mean 7.83 µl/min vs 9.07 µl/min, p=0.07). No significant difference was found between groups for the FAV or PFAV of the RTA. For the MEM, the difference between groups 1 and 3 approached significance for the 500 µm circle only (mean 0.64 vs 0.75, p=0.08). Conclusions: These results establish the baseline characteristics of a cohort of diabetics that are currently being followed over time with respect to retinal hemodynamics and retinal thickness. There was a difference between groups for visual acuity, type and extent of cataract and a trend toward differences in blood flow and edema index.

Keywords: diabetic retinopathy • clinical (human) or epidemiologic studies: nat • imaging/image analysis: clinical 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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