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A. Abri, S. Binder, A. Assadoullina, S. Brunner; Indocyanine Green Enhanced Vitreous Surgery . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4042.
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Purpose: To describe dosage and technique of the intravitreal use of ICG in a consecutive series of eyes with macular disease. Methods: ICG was used in 42 eyes of 40 patients from march 2001 to march 2002. Indications for surgery were MH (22) and MP (20) for either direct staining of the ILM or staining of the edges of a vitreoretinal membrane. Patients had complete clinical examinations before and after surgery, in addition, fluorescence angiography, multifocal electroretinography and optical coherence tomography were performed in 3 months intervals thereafter. In this study, visual acuity outcome and intra- and postoperative complications were compared with a control group operated the year before. Technique: The filtered and diluted (1.5 mg/ml) ICG is gently injected in the fluid filled vitreous cavity over the retinal surface. Not more than 0.2-0.4 ml of the solution are generally used. After contact time of 1 minute the ICG is rinsed from the vitreous cavity completely. An endgripping forceps is used to grasp and peel the dyed ILM or edges of the epiretinal membrane as complete as possible. Results: Visual acuity test did show better results in all indications if dye used. Intra- and postoperative complications were the same. Conclusions: : Based on our first results we belived that the current procedure with the dosage described is save. Dying of transparent membranes is clearly helpful in the understanding of the pathomechanism of the vitreoretinal interface and lead to lesser surgical trauma with more complete removal of the tissue. Better functional outcomes were found in our series, when compared with a control group. However, only long-term observation and controlled randomized studies will give us the final information.
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