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E. Asano, K. Mochizuki, Y. Kondo, A. Sawada, T. Yamamoto, E. Nagasaka; The Multifocal Electroretinogram in Normal-Tension Glaucoma . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4348.
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Purpose: To investigate the efficiency of multifocal electroretinogram (M-ERG) for glaucomatous optic neuropathy of normal-tension glaucoma (NTG). Methods: Thirteen eyes of 10 NTG patients (mean age, 58.5 years) with upper or lower hemifield defects detected with the Humphrey Field Analyzer (Program Central 30-2) and 20 normal subjects (mean age, 44.7 years) serving as controls were studied. M-ERG was recorded using a stimulus array of 37 hexagons for 4 minutes with a VERIS III. The central six responses were grouped into nasal and temporal ones. The first and second order kernels were analyzed. Result: The nasal amplitudes in the first order kernel were lager than the temporal ones in both normal subjects (p< 0.005) and NTG patients (upper hemifield defects: p=0.079; lower hemifield defects: p= 0.175). The nasal amplitude of the second order kernel was significantly lower than the temporal ones in normal subjects (p< 0.001), however there was no difference among nasal and temporal amplitudes in NTG patients. The ratio of nasal to temporal amplitude in second order kernel with NTG patients was significantly higher than that with normal subjects (upper hemifield defects: p< 0.001; lower hemifield defects: p< 0.05). There were no statistically significant differences in the latencies of both first and second order kernels between NTG patients and normal subjects. Conclusion: The central elements of the M-ERG of second order kernel reflect the retinal function of NTG patients.
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