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A. Pinheiro, M. Hatanaka, C. Morita, R. Susanna; Correlation Between Asymmetric Glaucomatous Visual Field Damage and Asymmetric Water Drinking Test Response . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4355.
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Purpose: To determine if there is a correlation between asymmetric glaucomatous visual field (VF) damage in eyes with similar mean basal intra-ocular pressure (IOP) levels between OU and Water Drinking Test (WDT) response. Methods: Retrospective analysis of VF and WDT data of 101 glaucomatous patients. Asymmetric VF classified by means of Mean Deviation (MD) values OD and OS. Similar basal mean IOP OU (maximum 2 mmHg difference between OD and OS) controlled with same medication in both eyes. Tukey's post-hoc multiple comparison test to compare WDT IOP levels of each eye. Student t-test to compare WDT response between eyes with higher MD and fellow eyes with lower MD values. Results: Mean age was 60.7±15.8 years old. The eyes were divided into two groups according to MD values. The mean MD was –4.62±5.34 dB in the group with higher MD values and –9.02±7.45 dB in the fellow eyes (p=0.0000001). Mean basal IOP was 13.93±3.15 mmHg in the higher MD group and 13.88±3.26 mmHg in the fellow eyes group with lower MD values (p=0.67, not statistically significant). At 15 minutes after ingestion of 1 liter of water, mean IOP was 15.36+3.63 mmHg in the group with higher MD values and 15.66±3.67 mmHg in the fellow eyes (p=0.03). At 30 minutes after water ingestion, mean IOP was 15.56±4.04 mmHg in the first group and 16.17±4.23 mmHg in the lower MD group (p=0.00379). At 60 minutes, mean IOP was 14.4±3.75 mmHg and 14.57±3.96 mmHg in each group (p=0.35). Conclusion: Eyes with lower MD values had the worst response curve during the WDT. This study shows a lower capacity of eyes with higher glaucomatous lesion to respond to a stimulus which leads to a transitory elevation of IOP.
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