May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Drug Delivery Intraocular Lens
S. Kobayakawa; K. Tanaka; A. Tsuji; H. Watanabe; Y. Tanahashi; T. Tochikubo
Author Affiliations & Notes
  • S. Kobayakawa
    The 1st Dept of Ophthalmology, Toho University Sch of Med, Ohta-Ku, Tokyo, Japan
  • K. Tanaka
    The 1st Dept of Ophthalmology, Toho University Sch of Med, Ohta-Ku, Tokyo, Japan
  • A. Tsuji
    Toho University Sch of Med, Ohta-Ku, Tokyo, Japan
  • H. Watanabe
    Toho University Sch of Med, Ohta-Ku, Tokyo, Japan
  • Y. Tanahashi
    Toho University Sch of Med, Ohta-Ku, Tokyo, Japan
  • T. Tochikubo
    Toho University Sch of Med, Ohta-Ku, Tokyo, Japan
  • Footnotes
    Commercial Relationships  S. Kobayakawa, None; K. Tanaka, None; A. Tsuji, None; H. Watanabe, None; Y. Tanahashi, None; T. Tochikubo, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4428. doi:
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      S. Kobayakawa, K. Tanaka, A. Tsuji, H. Watanabe, Y. Tanahashi, T. Tochikubo; Drug Delivery Intraocular Lens . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4428.

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Abstract

Abstract: : Purpose: Hydroview (H60M, Bausch&Lomb)intraocular lens(IOL) has a optic of a hydrophilic material. We experienced the case which needed to explant H60M IOL caused by optic opacification. The explanted IOL had been kept in the physiological saline, we observed the optic opacification disappeared. We investigated whether the H6OM has the function of drug delivery. Methods: 1. Five or six sheets of the fluorescein paper put in H60M container, and we observed pigmentary permeability after 24 hours. 2. Room temperature, under light shielding, the drug treatment H60M which was immersed in 0.5%LVFX eye drop for 24 hours and the un-treatment H60M were prepared.An inoculum of 10(8) cfu/ml was made from Escherichia coli (ATCC25922). An inoculum 0.1cc were applied to the heart infusion agar. The drug treatment H60M and un-treatment H60M, each was stood in the agar after washing. We observed after 24 hours culture at 35 degrees C. Results: 1.H60M dyed in the fluorescein was observed. 2.In the agar which stood the drug treatment H60M, there was the formation of the inhibition circle. Conclusions: It was confirmed that the water-soluble drug permeated at H60M and that it released it gradually. H60M seemed to have the possibility as drug delivery IOL.

Keywords: antibiotics/antifungals/antiparasitics • drug toxicity/drug effects 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
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