May 2003
Volume 44, Issue 13
ARVO Annual Meeting Abstract  |   May 2003
Influence of Donor Age on Penetrating Keratoplasty Outcome
Author Affiliations & Notes
  • I.N. Fedorovich
    Ophthalmology, University of Wisconsin, Madison, WI, United States
  • S. Verity
    Ophthalmology, University Of Texas Southwestern Medical Center, Dallas, TX, United States
  • L. Tseng
    Ophthalmology, Tulane University, New Orleans, LA, United States
  • Footnotes
    Commercial Relationships  I.N. Fedorovich, None; S. Verity, None; L. Tseng, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4667. doi:
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      I.N. Fedorovich, S. Verity, L. Tseng; Influence of Donor Age on Penetrating Keratoplasty Outcome . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4667.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: To report the influence of donor age on visual outcomes after corneal transplant. Materials and methods: Data was obtained by reviewing patient medical records for a series of 141 corneal transplants carried out at the Saint Louis University Eye Institute from 1996 to 1999. Results: Patients ranged from 12 to 89 years of age. Indications for corneal transplant were as follows: 51 (36%) due to pseudophakic/aphakic bullous keratopathy; 29 (20.5%)- previous transplant failure; 23 (16%)- corneal dystrophies; 21 (15%) - corneal scar; 9 (6%) - keratoconus; 5 (3.5%) - infectious keratitis; 2 (1.5%) - ruptured globe; 1 (0.5%) - staphyloma. Nine patients were excluded from the study because of loss to follow-up. For the purpose of analysis recipients were stratified to groups based upon age of the donor: group 1 (N=41) received tissue from donors 40 years of age or younger, group 2 (N=91) donors older than 40. Outcomes were determined by best-corrected visual acuities and were converted to logMAR values for statistical analysis. An odds ratio of 0.93 (confidence interval 0.41 – 2.11) indicated that there was no statistical difference between groups. Conclusion: In our study, the age of donor tissue did not influence visual outcomes of penetrating keratoplasty. Sample size limitations may have contributed to our inability to detect a difference between groups.

Keywords: clinical (human) or epidemiologic studies: out • cornea: clinical science • cornea: stroma and keratocytes 

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