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M. Sato, Y. Kaji, S. Amano, T. Oshika, T. Usui, K. Yamashiro, S. Ishida, A.P. Adamis, R. Nagai, S. Horiuchi; Expression of Advanced Glycation End Product (AGE) Receptors in Corneal Endothelial Cells . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4716.
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Purpose: Accumulation of advanced glycation end products (AGEs) via the specific receptors plays an important role in the aging process. In the present study, we investigated the localization of AGE and the expression of AGE receptors (receptor for AGE (RAGE) and galectin-3) in the corneal endothelial cells. Methods: Localization of AGEs was immunohistochemically investigated in human corneas of 12 adult (6 non-diabetics and 6 diabetics) and 2 fetal subjects. In bovine corneal endothelial cells, the expression of RAGE and galectin-3 was assessed at the mRNA and protein levels. Results: AGE was not detected in the fetal corneal endothelium, but was found in the corneal endothelium of adult subjects irrespective to the presence of diabetes. The expression of RAGE and galectin-3 was detected in the corneal endothelium of bovine corneas. Conclusions: AGE and AGE receptors were detected in the corneal endothelium of adult corneas, but not of fetal corneas. Accumulation of AGE via AGE receptors may be one of the factors that are responsible for the aging process of corneal endothelium.
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