May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Expression of Advanced Glycation End Product (AGE) Receptors in Corneal Endothelial Cells
M. Sato; Y. Kaji; S. Amano; T. Oshika; T. Usui; K. Yamashiro; S. Ishida; A.P. Adamis; R. Nagai; S. Horiuchi
Author Affiliations & Notes
  • M. Sato
    Dept of Ophthalmology, University of Tsukuba, Tsukuba Ibaraki, Japan
  • Y. Kaji
    Dept of Ophthalmology, University of Tsukuba, Tsukuba Ibaraki, Japan
  • S. Amano
    Dept of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
  • T. Oshika
    Dept of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
  • T. Usui
    Dept of Ophthalmology, University of Tokyo, Tokyo, Japan
  • K. Yamashiro
    Dept of Ophthalmology, University of Kyoto Graduate School of Medicine, Kyoto, Japan
  • S. Ishida
    Dept of Ophthalmology, University of Keio School of Medicine, Tokyo, Japan
  • A.P. Adamis
    Dept of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, United States
  • R. Nagai
    Dept of Biochemistry, University of Kumamoto School of Medicine, Kumamoto, Japan
  • S. Horiuchi
    Dept of Biochemistry, University of Kumamoto School of Medicine, Kumamoto, Japan
  • Footnotes
    Commercial Relationships  M. Sato, None; Y. Kaji, None; S. Amano, None; T. Oshika, None; T. Usui, None; K. Yamashiro, None; S. Ishida, None; A.P. Adamis, None; R. Nagai, None; S. Horiuchi, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4716. doi:
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      M. Sato, Y. Kaji, S. Amano, T. Oshika, T. Usui, K. Yamashiro, S. Ishida, A.P. Adamis, R. Nagai, S. Horiuchi; Expression of Advanced Glycation End Product (AGE) Receptors in Corneal Endothelial Cells . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4716.

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Abstract

Abstract: : Purpose: Accumulation of advanced glycation end products (AGEs) via the specific receptors plays an important role in the aging process. In the present study, we investigated the localization of AGE and the expression of AGE receptors (receptor for AGE (RAGE) and galectin-3) in the corneal endothelial cells. Methods: Localization of AGEs was immunohistochemically investigated in human corneas of 12 adult (6 non-diabetics and 6 diabetics) and 2 fetal subjects. In bovine corneal endothelial cells, the expression of RAGE and galectin-3 was assessed at the mRNA and protein levels. Results: AGE was not detected in the fetal corneal endothelium, but was found in the corneal endothelium of adult subjects irrespective to the presence of diabetes. The expression of RAGE and galectin-3 was detected in the corneal endothelium of bovine corneas. Conclusions: AGE and AGE receptors were detected in the corneal endothelium of adult corneas, but not of fetal corneas. Accumulation of AGE via AGE receptors may be one of the factors that are responsible for the aging process of corneal endothelium.

Keywords: cornea: endothelium • aging • cornea: basic science 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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