May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Correlation of Visual Acuity with Pachymetry in Patients with Fuchs' Endothelial Dystrophy
Author Affiliations & Notes
  • A.M. Oboh
    Ophthalmology, The Johns Hopkins Hospital , Wilmer Eye Institute, Baltimore, MD, United States
  • H. Lai
    Ophthalmology, The Johns Hopkins Hospital , Wilmer Eye Institute, Baltimore, MD, United States
  • F. Weilke
    Diagnostic Imaging, University of Connecticut Health Center, Farmington, CT, United States
  • J. Rafaie
    School of Medicine, Georgetown University, Washington, DC, United States
  • A.S. Jun
    School of Medicine, Georgetown University, Washington, DC, United States
  • W.J. Stark
    School of Medicine, Georgetown University, Washington, DC, United States
  • J.D. Gottsch
    School of Medicine, Georgetown University, Washington, DC, United States
  • Footnotes
    Commercial Relationships  A.M. Oboh, None; H. Lai, None; F. Weilke, None; J. Rafaie, None; A.S. Jun, None; W.J. Stark, None; J.D. Gottsch, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4742. doi:
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      A.M. Oboh, H. Lai, F. Weilke, J. Rafaie, A.S. Jun, W.J. Stark, J.D. Gottsch; Correlation of Visual Acuity with Pachymetry in Patients with Fuchs' Endothelial Dystrophy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4742.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To evaluate the relationship between pachymetry and visual acuity in patients diagnosed with Fuchs' endothelial dystrophy. Methods: Records of patients with Fuchs' dystrophy seen at the Wilmer Eye Institute between 1995-2002 were retrospectively reviewed. Data on age, sex, visual acuity, pachymetry, intraocular pressure and diagnosis of eye diseases were collected. Patients with cataracts and other ocular pathologies or those who had undergone prior intraocular surgery were excluded from the study. Data analysis was performed using the Generalized estimating equations (GEE) method. Pachymetry was treated as an independent variable, and LogMar as a dependent variable. Results: Records of 102 patients (204 eyes) over a time course of 7 years were abstracted. The female to male ratio was 2.1:1. At baseline, patients aged 20 to 90 years (means±SD: 66.4±13.3). Corneal thickness ranged from 420 to 900 µm and LogMar values ranged from -0.1249 to 1.3010. After the adjustment for age, visit and two eyes of each patient, pachymetry was positively correlated with LogMar; an average of 0.0239 increase in LogMar for every 100 µm increment in pachymetry, (p <0.0001). Further more, the higher corneal thicknesses, defined as pachymetry >600 µm were positively associated with visual acuity worse than 20/40 (LogMar > 0.3010). Also, patients with higher corneal thicknesses were twice as likely to have 20/40 vision or worse (OR and 95% CI: 2.67 and 1.72-4.15). Conclusion: In Fuchs' dystrophy patients, decreasing visual acuity correlates with increasing pachymetry. Larger increases in pachymetry (>100um) were required before substantial decreases in visual acuity were observed, and patients with pachymetry <600um showed relatively minor decreases in visual acuity. These findings may impact on current practice patterns to perform combined corneal transplant and cataract surgery in Fuchs' dystrophy.

Keywords: cornea: endothelium • cornea: clinical science 
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