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P. Lanzetta, F. Ortolani, L. Petrelli, U. Cugini, F. Bandello, M. Marchini; Irradiation of Rabbit Retina and Initial Clinical Experience with a Red Diode Laser (670 nm) . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4856.
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Purpose: To verify the histopathology of a red diode laser emitting at 670 nm in pigmented rabbit retina and to investigate its clinical use in the treatment of a number of retinal diseases. Methods: Transpupillary laser pulses with a prototype (Biolitec AG) for use in conjunction with a standard slit lamp microscope were applied to pigmented rabbit retina. Samples were processed for light and electron microscopy immediately after exposure. Subsequently, after informed consent was obtained, seventeen eyes of seventeen patients were treated for conditions such as proliferative diabetic retinopathy, central retinal vein thrombosis, rhegmatogenous retinal lesions and retinal breaks. Results: In pigmented rabbit, threshold lesions were induced using a power of 300 mW, a spot size of 500 microns and exposure time of 0.2 seconds. Damage was incurred by the retinal pigment epithelium with extension into the outer retina anteriorly and limited involvement of the superficial and mid choroid posteriorly. Retinal whitening was obtained in all the patients treated either with a three-mirror Goldmann lens or a Quadraspheric lens. Regression of retinal neovascularization and adhesive pigmented scars were observed. Current major limitations of the prototype are related to the low intensity of the aiming beam (0.4 mW), limited power (0.6 W) and relatively large minimum spot size (160 microns). Conclusions: The histological characteristics of the lesions produced by a red diode laser emitting at 670 nm and the initial clinical experience suggest the use of this wavelength in the treatment of retinal pathologies.
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