May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Comparative Study of Macular Holes Using Ultrahigh Resolution and Standard Optical Coherence Tomography
J.G. Fujimoto; T.H. Ko; J.S. Schuman; J. Duker; L.A. Paunescu; A.M. Kowalevicz; I. Hartl; W. Drexler; H. Ishikawa; G. Wollstein
Author Affiliations & Notes
  • J.G. Fujimoto
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States
  • T.H. Ko
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States
  • J.S. Schuman
    New England Eye Center, Tufts-New England Medical Center, Boston, MA, United States
  • J. Duker
    New England Eye Center, Tufts-New England Medical Center, Boston, MA, United States
  • L.A. Paunescu
    New England Eye Center, Tufts-New England Medical Center, Boston, MA, United States
  • A.M. Kowalevicz
    New England Eye Center, Tufts-New England Medical Center, Boston, MA, United States
  • I. Hartl
    New England Eye Center, Tufts-New England Medical Center, Boston, MA, United States
  • W. Drexler
    Institute of Medical Physics, University of Vienna, Vienna, Austria
  • H. Ishikawa
    Institute of Medical Physics, University of Vienna, Vienna, Austria
  • G. Wollstein
    Institute of Medical Physics, University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships  J.G. Fujimoto, Carl Zeiss Meditec F, P; T.H. Ko, None; J.S. Schuman, Carl Zeiss Meditec F, P; J. Duker, None; L.A. Paunescu, None; A.M. Kowalevicz, None; I. Hartl, None; W. Drexler, None; H. Ishikawa, None; G. Wollstein, None.
  • Footnotes
    Support  NIH EY11289-14, EY1317802, P30-EY13078, FWF P14218-PSY, FWF Y159, CRAF-1999-70549
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4861. doi:
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      J.G. Fujimoto, T.H. Ko, J.S. Schuman, J. Duker, L.A. Paunescu, A.M. Kowalevicz, I. Hartl, W. Drexler, H. Ishikawa, G. Wollstein; Comparative Study of Macular Holes Using Ultrahigh Resolution and Standard Optical Coherence Tomography . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4861.

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Abstract

Abstract: : Purpose: To perform a comparative imaging study of idiopathic macular holes using ultrahigh resolution (UHR) optical coherence tomography (OCT) versus standard resolution OCT. To investigate cases where the improved visualization of UHR OCT yields improved information on macular hole morphology, pathogenesis, and repair. To apply UHR OCT results to improve the interpretation of standard resolution OCT images. Methods: A new ultrahigh resolution UHR OCT system has been developed which enables imaging in the ophthalmic clinic using a high performance, low cost, compact femtosecond laser light source. The UHR OCT instrument achieves axial image resolutions of better than 3 µm and image sizes of 3000 axial pixels by 600 transverse pixels. Comparative studies are performed using a commercial OCT3 instrument with a 10-15 µm axial resolution. UHR and standard resolution OCT imaging are performed in the same patients and results correlated with standard ophthalmoscopic examination including fundus photography, and fluorescein angiography. Results: To date, more than 100 patients have been imaged with a wide range of retinal pathologies. Patients with idiopathic macular holes of various stages, atypical macular holes, and vitreomacular traction have been imaged with both UHR and standard resolution OCT. The improved axial resolution of the UHR OCT enables better visualization of intraretinal architectural morphology than standard resolution OCT. UHR OCT is especially powerful for visualizing pathology of the photoreceptor inner and outer segments and the external limiting membrane which are difficult to see with standard resolution. UHR imaging explains the outcomes of macular hole therapy and recovery of visual function. At the same time, UHR OCT provides a baseline for interpreting features seen with standard resolution OCT. Conclusions: UHR OCT enables better visualization of macular hole pathologies than standard resolution OCT and is especially powerful for elucidating changes in intraretinal architectural morphologies associated with various stage macular holes. Comparative studies of UHR and standard resolution OCT also provide a baseline for better interpretation of standard resolution OCT.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, S • imaging/image analysis: clinical • retina 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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