May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Oxygen Saturation Level in the Fundus of Retinal Dystrophy
K. Murayama; M. Ito; M. Shibuya; T. Deguchi; M. Takasu; S. Yoneya
Author Affiliations & Notes
  • K. Murayama
    Department of Ophthalmology, Saitama Medical School, Iruma, Japan
  • M. Ito
    Department of Ophthalmology, Saitama Medical School, Iruma, Japan
  • M. Shibuya
    Department of Ophthalmology, Saitama Medical School, Iruma, Japan
  • T. Deguchi
    Department of Ophthalmology, Saitama Medical School, Iruma, Japan
  • M. Takasu
    Department of Ophthalmology, Saitama Medical School, Iruma, Japan
  • S. Yoneya
    Department of Ophthalmology, Saitama Medical School, Iruma, Japan
  • Footnotes
    Commercial Relationships  K. Murayama, None; M. Ito, None; M. Shibuya, None; T. Deguchi, None; M. Takasu, None; S. Yoneya, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4869. doi:
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      K. Murayama, M. Ito, M. Shibuya, T. Deguchi, M. Takasu, S. Yoneya; Oxygen Saturation Level in the Fundus of Retinal Dystrophy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4869.

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Abstract

Abstract: : Purpose: To investigate oxygen saturation (OS) levels in the fundus represents in retinal dystrophy. Methods: Eighteen eyes of 9 rod-cone dystrophy patients and 4 eyes of 2 cone-rod dystrophy patients from 23 to 65 years of age and 10 normal controls from 24 to 62 years of age were studied. Besides fundus examination, visual field, electroretinograms and the measurement of retinal oxygen saturation were performed in all patients. We used Retinal Cube system (Applied Spectral Imaging Ltd, Israel) called retinal oxymeter that calculates the OS by two dimension non-invasively (Yoneya et al, 2002). The oxygen map of the fundus displayed with corresponding colors ranging from dark purple (representing oxygen levels of less than 40%) to red (representing 100% oxygen level). The system allows the measurement of a spectrum at every pixel and we measured the points on the temporal-superior, temporal-inferior, and macula lesions. Results: The OS levels in the most areas of normal retina were more than 80% and the OS level in the macular lesion tended to be lower than that of the other retinal lesion. The mean OS levels of the temporal-superior and temporal-inferior retina were 87.4±5.9 in normal subjects, 76.0±7.0 in rod-cone dystrophy, and 77.5±4.0 in cone-rod dystrophy. The retinal OS level in retinal dystrophy was significant lower than that of normal subjects (P<.05). The OS levels in the macula lesion were 65.7±2.6 in normal subjects, 68.7±7.4 in rod-cone dystrophy, and 57.7±7.0 in cone-rod dystrophy. The OS level in the macula of cone-rod dystrophy was significantly lower than that of normal subjects (P<.05). Conclusions: Retinal OS level significantly decreased in patients with retinal dystrophy. The OS level in macular lesion of cone-rod dystrophy showed different pattern from that of rod-cone dystrophy. These phenomena might be important clinical feature to understand the pathogenesis of retinal dystrophy.

Keywords: imaging/image analysis: clinical • retinal degenerations: hereditary • retina 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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