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J.N. Nam, M. Kirzhner, C.J. Clemens, K. Holopigian, W. Seiple; Reliability of Perimetry: Measures of Acuity, Contrast Sensitivity, and Luminance Detection . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4903.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: The ability to precisely measure retinotopically localized functional vision will become increasingly useful to assess the effects of intervention procedures that are currently in practice and/or being developed. We have developed methods that compare visual field sensitivities measured using the Humphrey Visual Field Analyzer to perimetry measured using higher-level psychophysical tasks (e.g., letter acuity and grating contrast sensitivity; Seiple et al., ARVO 2002). In the current work, we assessed the reliability of our measures in order to develop metrics by which we could assess the statistical probability of observed perimetry changes in patients. Methods: Luminance sensitivity (at 10 and 100 cd/m2 mean luminance), letter acuity and grating contrast sensitivity were measured at 13 locations within the central 10 degrees of the visual field. Thresholds were also obtained at the same retinal locations using the Humphrey Visual Field Analyzer. Data from five normally sighted control subjects were obtained on a weekly basis for six weeks. Results: For each measure, inter-visit change scores were calculated. For the Humphrey, inter-visit threshold variations averaged -0.06 + 1.6 db across all positions and all subjects. For spot luminance, thresholds increments averaged 0.1 + 0.5 cd/m2 for the 100-cd/m2 and 0.09 + 0.2 cd/m2 for the 10-cd/m2 conditions. For letter acuity, the average change was 0.18 + 0.9 minarc, and for contrast sensitivity, the average change was 0.4 + 0.9%. Conclusions: These results demonstrate that perimetry measured using luminance defined spatial targets is reliable and can be used to accurately assess the effects of therapeutic interventions.
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