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L.C. Ferraz, S.A. Schellini, E.A. Gregório, S.S. Muller, C.A. Silveira; The Ganglion Cell Layer Following Induced Chronic Alcoholism in Rats . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4915.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: to evaluate the effects of chronic ethanol feeding on the ganglion cell layer in an adult rat model. Methods: five "treated" rats (TG) were fed with standard lab rodent chow and an ethanol-containing liquid, and 4 "control" animals (CG) were fed chow and tap water for 40 weeks. The eyes were removed and the retina was prepared to ultrastructural examination. The ganglion cell layer was evaluated by transmission electron microscopy. Results: it was observed in the layer studied ganglion cells, some glial cells and portions of the Müller cells between the neurons axons. There were also some vessels. Comparing the groups, the ganglion cells in the TG animals presented nuclear and cytoplasmic alteration. At the nuclei, was observed membranous nuclear separation and dispersed chromatin and at the cytoplasm dilated reticulum, mitochondrial edema, vacuoles with Myelin figures. Even though in the TG animals the axons showed several alterations as neurotubules diminished and vacuoles. Conclusion: these findings suggest that chronic ethanol exposure induce ganglion cell layer degeneration in rats.
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