May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
The Effect of Ginkgo biloba in Experimental Ischemic Retina After Photodynamic Injury
H.G. Yu; K.S. Choi; J. Heo; H. Chung; J.Y. Oh
Author Affiliations & Notes
  • H.G. Yu
    Ophthalmology, Seoul National University School of Medicine, SAEC, Seoul, Republic of Korea
  • K.S. Choi
    Ophthalmology, Seoul National University School of Medicine, SAEC, Seoul, Republic of Korea
  • J. Heo
    Ophthalmology, Seoul National University School of Medicine, SAEC, Seoul, Republic of Korea
  • H. Chung
    Ophthalmology, Seoul National University School of Medicine, SAEC, Seoul, Republic of Korea
  • J.Y. Oh
    Ophthalmology, Seoul National University School of Medicine, SAEC, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  H.G. Yu, None; K.S. Choi, None; J. Heo, None; H. Chung, None; J.Y. Oh, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4922. doi:
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      H.G. Yu, K.S. Choi, J. Heo, H. Chung, J.Y. Oh; The Effect of Ginkgo biloba in Experimental Ischemic Retina After Photodynamic Injury . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4922.

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Abstract

Abstract: : Purpose: To examine the effect of Ginkgo biloba ( in retinal ischemia model by retinal vein occlusion after photodynamic injury. Methods: Photothrombosis was produced in central retinal vein by the combination of intravenous injection of rose bengal (photosensitive dye). Ginkgo biloba (20, 100mg/kg) was injected orally with carboxymethylcellulose once a daily for 7days before photodynamic injury and 2 weeks after. Eyes were examined at intervals during the subsequent day with ophthalmoscopy, fluorescein angiography, photograpy. Rats were killed 2weeks after injury and ischemic retinal cell death was detected with TUNEL stain and histopathologic feature. Results: Retinal detachments developed 1 or 2 day after laser treatment, and reperfusion of occluded vein was noted 5 or 7 days after injury. New vessels was first noted 12days after injury. In no treatment group, severe disarrangement of retina and new vessel were more developed than treated groups. Conclusions: Ginkgo biloba provide protection to the retina from ischemia.

Keywords: vascular occlusion/vascular occlusive disease • neovascularization • ischemia 
© 2003, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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