Purchase this article with an account.
R.M. Niknam, L.S. Schocket, J.C. DuPont, T.I. Metelitsina, J.E. Grunwald; Effect of Systemic Hypertension on Foveolar Choroidal Hemodynamics . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4928.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: Systemic hypertension (SH) is a known risk factor for age-related macular degeneration and diabetic retinopathy. We assessed the effect of systemic hypertension on the choroidal circulation. Methods: Laser Doppler flowmetry (Oculix) was used to determine relative choroidal blood velocity (Chvel), volume (Chvol), and flow (Chflow) in the center of the fovea. After pupillary dilatation was achieved, hemodynamic parameters were measured by asking study participants to fixate on a probing laser beam. Measurements were obtained in one eye of thirty subjects. Fifteen subjects had SH and fifteen were age-matched healthy controls. Twelve of the 15 subjects with SH were on antihypertensive medications and three were not receiving medication because they had been recently diagnosed. Average known duration of SH was 11±6 years (mean±SD). All subjects included had no clinical evidence of progressive intraocular disease. Following blood flow measurements heart rate and blood pressure were measured. Results are shown in arbitrary units (AU). Results: We found no significant differences in Chvel, Chvol, and Chflow between subjects with systemic hypertension and controls in spite of the fact that mean blood pressure was 12.4% higher in the subjects with SH (t-test, p=0.007). When all the subjects were analyzed together, a significant inverse correlation between Chflow and age was found Chflow (r=-0.388, p=0.034) confirming our previous findings (Arch Ophthalmol 1998;116:150). Because we did not detect any significant effect of hypertension on Chflow we estimated that we have an 84% power to detect a 35% difference in Chflow between the two groups. Conclusion: SH does not seem to have a large effect on the choroidal circulation in hypertensive subjects that are controlled by antihypertensive therapy or in subjects with a recent diagnosis. Further studies are needed to clarify if SH has an effect on the choroidal circulation in patients with ocular disease. View OriginalDownload SlideView OriginalDownload Slide
This PDF is available to Subscribers Only