Abstract
Abstract: :
Purpose: To assesse macular function using multifocal electroretinogram (mfERG) in a subset of elder patients with macular pucker, subretinal CNV and drusen. Methods: 18 eyes of 17 patients (aged 56~75 Yrs, mean 67.12±5.41Yrs) suffered from macular pucker, with a best corrected visual acuity of 4/40 to10/40.10 eyes of 9 patients (aged 55~69 Yrs,mean 60.89±4.37 Yrs) suffered from subfoveal choroidal neovascularization (CNV) due to age-related macular degeneration (AMD), with a best corrected visual acuity of 4/40 to32/40. 16 eyes of 10 patients (aged 54~80 Yrs, mean 69±7.7 Yrs) suffered from macular drusen,with a best corrected visual acuity of 8/40 to36/40. 15 eyes of 15 patients (aged 55~76 Yrs, mean 62.53±6.62 Yrs) without any eye abnormalities were included as contrast, with an uncorrected visual acuity of 40/40 or better. For each patient multifocal Electroretinograms (mfERGs) were recorded using Roland RetiScan System (V3.12) with dilated pupils and ERG-Jet electrodes. To stimulate the retina we used a CRT monitor to generate hexagonal elements (altogether 61), which may pseudo-randomly change in contrast between white and black (m-sequences). There were 5 rings in 24° visual angle. The amplitude and latency times of a, b waves were measured for the first-order kernel response and averaged within 2 concentric rings radiating from the fovea. Results: Comparing to the contrast, the b wave amplitudes of ring 1 of eyes suffered from macular pucker, subretinal CNV and drusen were significantly lower p=0.007. The amplitudes of a wave(p=0.018) and b wavep=0.007of ring 2 were significantly lower in macular pucker eyes. The results of the other eye of these patients were normal. The amplitudes of a wave(p=0.001) and b wavep=0.004 of ring 2 were significantly lower in subretinal CNV eyes. The latency times of a wave were longer p=0.021.The latency times of a, b waves of ring 1 were longer p=0.018p=0.031 in the other eyes. Comparing to the contrast in eyes suffered from macular drusen the amplitude of a wave(p=0.003), b wavep=0.000 of ring 2 were significantly lower. Conclusions: The amplitudes of a and b waves of ring 1 and 2 decreases in patients with macular pucker, subretinal CNV and drusen. The amplitude of b wave is more vulnerable. CNV would delay a and b waves. The latency times of a, b waves of ring 1 were longer in the other eyes of CNV patients which indicates functional changes in the macula. Patients with macular pucker usually have good visual acuty. The decrease of the amplitude of a and b waves in the current study indicates macular malfunction in these patients.
Keywords: macula/fovea • electroretinography: clinical • drusen