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K. Schwanitz, L.E. Pillunat; Results of a Long Term Study Regarding Causes for Disorders of Ocular Perfusion . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4958.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: The exact cause detection for a disorder in ocular Perfusion (CRAO, BAO, AION, PION, CRVO, BVO) is subject of debates. This study aims at the evaluation of possible sources. Methods: In a prospective study during a period of 63 month we examined 341 patients with a disorder in ocular Perfusion (OPS) (192 male/149 female, average age 61.8 years, 217 venous OPS, 124 arterial OPS). We performed blood analyzes, blood pressure measurements, ECG, Doppler ultra-sonographic analyzes of the Carotides and the orbital vessels, ocular pressure measurements, and consulted ear nose and throat specialists, stomatologists, internists, and gynecologists as required. Additionally we carried out screenings for diseases of blood coagulation, collagenoses, and selected causative agents. For a period of 10 days we applied isovolemic Hemodilution treatment (IHT) with a target hematocrit value HK ≤ 0,37. Results: We have been able to identify the main cause or a combination of different causes for OPS in 231 examined patients (67.7%). This corresponds to 70 arterial OPS (56,4%) and 161 venous OPS (74,2%). The measured sources can be assigned to hypertonical disease (51.8%), general inflammation (12.6%), collagenoses (4.9%), disease of blood coagulation (2.7%), and another focus (2.5%). In 110 cases (32,3%) the relevant cause could not be determined. Out of these 110 cases the formation of an OPS in the second eye could be observed in 6 patients (4 venous OPS as in the first eye, 2 arterial OPS as in the first eye) within 6 to 18 month (average 12 month). Conclusions: The thorough cause study represents the fundamental condition for deriving the adequate treatment of OPS.
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