May 2003
Volume 44, Issue 13
ARVO Annual Meeting Abstract  |   May 2003
Microvascular Rearrangement following Branch Retinal Vein Occlusion in Rats
Author Affiliations & Notes
  • M. Paques
    Opthalmology, Fondation Ophtalmologique Rothschild, Paris, France
  • O. Genevois
    Opthalmology, CHU, Rouen, France
  • R. Sercombe
    Laboratoire de Recherches Cérébrovasculaires, Paris, France
  • J. Seylaz
    Laboratoire de Recherches Cérébrovasculaires, Paris, France
  • A. Gaudric
    Opthalmology, CHU Lariboisière, Paris, France
  • E. Vicaut
    Laboratoire d'Etude de la Microcirculation, Paris, France
  • Footnotes
    Commercial Relationships  M. Paques, None; O. Genevois, None; R. Sercombe, None; J. Seylaz, None; A. Gaudric, None; E. Vicaut, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4963. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      M. Paques, O. Genevois, R. Sercombe, J. Seylaz, A. Gaudric, E. Vicaut; Microvascular Rearrangement following Branch Retinal Vein Occlusion in Rats . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4963.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Abstract: : Purpose: To analyze the microvascular remodeling following transient branch vein occlusion in rats. Methods: Branch retinal vein occlusion was induced in pigmented rats by laser photocoagulation. Confocal microscopy of fluorescein-dextran filled vessels was performed 1, 3, 8 and 30 days after laser treatment (n=4 in each group). The changes in morphology and density of microvessels upstream of the occlusion site within each layer were evaluated by serial optical sectioning. Results: At day 1, dilation of venules and capillary closure in the intermediate and deep microvessel layers were present. Following repermeabilization at day 3, venule dilation and capillary closure areas showed transient aggravation, then only partially regressed. At day 30 capillary density was reduced by 24% in the deep layer and by 62% in the intermediary layer. At all time points the superficial layer remained unaffected. Control and sham-treated retinas showed no changes. Conclusions: Following transient vein obstruction, the deep microvessel layer at the level of the outer plexiform layer is the most severely affected by capillary closure while the superficial layer appears unaffected. Following reperfusion of the occluded vein, these microvascular changes only partially regress. This suggest that treatments aimed at repermeabilizing an occluded vein should be applied early in order to avoid permanent retinal damage.

Keywords: vascular occlusion/vascular occlusive disease • pathology: experimental • ischemia 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.