Efficacy of Photodynamic Therapy in Treatment of Circumscribed Choroidal Hemangioma

Abstract

Abstract: : Purpose: To report efficacy of photodynamic therapy (PDT) in treatment of 3 cases of juxtafoveal circumscribed choroidal hemangioma. Methods: Data on 3 patients (2 primary, and 1 failed TTT) treated with verteporfin, 6mg/m² given as IV infusion over 10 minutes. Diode laser (690 nm) with an intensity of 600 mW/cm² for 83 seconds (50mJ/cm²) was applied 5 minutes after completion of infusion. Overlapping multiple spots (2500 micron) were applied to cover the entire surface of the tumor. The mean pretreatment tumor size was 7 mm (base) x 2.2 (thickness) mm. Periodic follow-up with ophthalmoscopy, ultrasonography, and angiographic studies was performed. Results: All three cases showed complete regression of the tumor with resolution of subretinal fluid, flattening of tumor, and absence of choroidal vasculature on ICG. The visual acuity either improved or remained stable in all three cases. The overlying retinal vessels remained unaffected. There were no ocular systemic or complications. Conclusions: PDT is an effective treatment for management of juxtafoveal circumscribed choroidal hemangioma.  

Keywords: photodynamic therapy • choroid • oncology