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B.H. Fuisting, M. Feucht, G. Richard; Transpupillary Thermotherapy (TTT) of Malignant Choroidal Melanoma - Follow Up After 15 Months . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4974.
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Purpose: For the treatment of small choroidal melanomas (<3.0mm) or residual tumors after brachytherapy recently Transpupillary Thermotherapy is used increasingly. Methods: 40 patients with a small primary malignant melanoma (20 patients) or after preceded brachytherapy (20 patients) were treated with Transpupillary Themotherapy. Infrared diode laser light at 810nm was used to apply laser spots of about 3000µm. Laserenergy >800mW was needed to achieve visible effects after 60 seconds duration. A complete ophthalmologic examination including visual acuity, slit-lamp biomicroscopy, funduscopy, ultrasound and fluorescein angiography was performed prior to and after the treatment. Results: After 15 months in 26 (65%) of the patients a complete occlusion of the treated tumor vessels was observed. In 14 patients (35%) a residual tumor activity could be identified in fluorescein angiography. In 16 patients TTT was necessary only one time to get a complete remission of the tumor, the remaining 24 patients received a repeated TTT-therapy without any problems. Conclusions: Transpupillary Thermotherapy is proven to be an effective and save therapy for patients with residual tumors or small choroidal melanoma. During the observed period none of the patients required enucleation and only one patient needed an additional brachytherapy.
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