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M.M. Altaweel, B.A. Blodi, J.N. Ver Hoeve; Complications of Age-Related Macular Degeneration Prevention Trial (CAPT) – Evaluation of Retinal Function in Treated versus Control Eyes with Multifocal Electroretinography . Invest. Ophthalmol. Vis. Sci. 2003;44(13):5011.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To assess the electroretinographic function in a subset of participants with age- related macular degeneration who have received prophylactic laser treatment in one eye as part of the CAPT study. Methods: Multifocal electroretinography (MERG) was performed in 20 subjects for both eyes at baseline, and at 3 months and 2 years following application of prophylactic laser according to the CAPT protocol in one eye. Analysis was performed utilizing 3 rings which correspond to the central macula, the ring in which laser is applied, and a peripheral ring. Comparison was performed between control and treated eyes at each timepoint, and within each group for changes over the 2 year followup. Results: At baseline, control and treated eyes had equivalent MERG first-order kernel responses (response density and peak latencies) in all three rings (p > 0.1). Over the two years, there was a slight increase in peak latency (range 1-4 ms) of outer retinal MERG first order responses, (p < 0.01), however the increase was equivalent in control and treated eyes. There is no significant difference between the two groups at 2 years. Conclusions: Administration of low intensity laser in a grid encircling the central macula does not result in any significant changes in MERG response when compared to fellow (control) eyes. This demonstrates one measure of safety of the procedure.
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