May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
OCT Features in Vitelliform Macular Dystrophy (Best's Disease)
Author Affiliations & Notes
  • N. Leveziel
    Ophthalmology, university Paris XII, Créteil, France
  • E. Souied
    Ophthalmology, university Paris XII, Créteil, France
  • N. Benhamou
    Ophthalmology, university Paris XII, Créteil, France
  • G. Coscas
    Ophthalmology, university Paris XII, Créteil, France
  • G. Soubrane
    Ophthalmology, university Paris XII, Créteil, France
  • Footnotes
    Commercial Relationships  N. Leveziel, None; E. Souied, None; N. Benhamou, None; G. Coscas, None; G. Soubrane, None.
  • Footnotes
    Support  eye grant ey2003
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 5102. doi:
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      N. Leveziel, E. Souied, N. Benhamou, G. Coscas, G. Soubrane; OCT Features in Vitelliform Macular Dystrophy (Best's Disease) . Invest. Ophthalmol. Vis. Sci. 2003;44(13):5102.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To correlate fundus examination with OCT features in Vitelliform Macular Dystrophy (VMD). Methods: A complete ophthalmic examination was performed on 21 patients affected with VMD, including best corrected visual acuity, fundus examination, red-free frames and OCT examination. We performed 57 OCT with 6 different sections per eye (342 sections). Results: The results were compared with fundus examination at different stages of disease. At vitelliform stage, the OCT sections shown an elevated and hyporeflective lesion localised under the level of the retinal pigmentary epithelium (RPE). Retinal layers appeared normal at this stage. At the pseudo-hypopion stage, OCT showed hyporreflectivity at the superior part of the lesion and hyperreflectivity at the inferior part of the lesion within the RPE band.At the scramble-egg stage, the lesion appeared hyporreflective with some hyperreflectif areas. At the fibrotic stage, a hyperreflective lesion was observed, extending from the RPE level to the superficial layers of retina, that appeared thinned and severely impaired. Conclusions: OCT is a non invasive and useful tool allowing correlations with fundus examination at every stage of the disease. OCT clearly distinguishes the vitelliform stage from the fibrotic stage. In VMD, OCT shows vitelliform material accumulated under the RPE band, these data are in agreement with our knowledge about histopathologic reports.

Keywords: retinal degenerations: hereditary • pathology: human • retina 
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