May 2003
Volume 44, Issue 13
ARVO Annual Meeting Abstract  |   May 2003
Ketamine Neuroprotection in the Rabbit Retina after Pars Plana Vitrectomy with Silicone Oil Tamponade
Author Affiliations & Notes
  • J.A. Cardillo
    Araraquara, Brazil
  • Retina Research Team
    Araraquara, Brazil
  • Footnotes
    Commercial Relationships  J.A. Cardillo, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 5241. doi:
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      J.A. Cardillo, Retina Research Team; Ketamine Neuroprotection in the Rabbit Retina after Pars Plana Vitrectomy with Silicone Oil Tamponade . Invest. Ophthalmol. Vis. Sci. 2003;44(13):5241.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: To verify the neuroprotective potential of ketamine in the rabbit retina after pars plana vitrectomy with silicone oil tamponade. Methods: Twenty young albino rabbits underwent standard three port pars plana vitrectomy with intravitreal silicone oil injection. The rabbits were then randomized into 2 groups. Group I received an intramuscular daily dose of 50 mg/ml of ketamine and group II received an intramuscular daily injection of saline. The animals were euthanized 4 weeks after vitrectomy and the eyes processed for light microscopy. Qualitative and quantitative analysis of the retinal cells were made using Zeiss Axioplot microscope and KS400 software (Carl Zeiss Vision).Results: Light microscopy showed a higher rate of picnotic nuclei in retinas from group II. Group I retinal cell density from the inner nuclear and ganglionar cell layers was significantly higher (student's-t-test) in group I retinas when compared to Group II. Although retinal cell density from the outer nuclear layer was higher in Group I, the difference was not statiscally significant. Conclusions: Ketamine was effective in reducing retinal cell death related to silicone oil injury one month after vitrectomy.

Keywords: neuroprotection • retina • pharmacology 

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