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HS Uy, JM G Reyes, JP Flores, R Limbonsiong; Human Plasma Derived Fibrin Glue (Beriplast P) in Conjunctival Autografts for Pterygia . Invest. Ophthalmol. Vis. Sci. 2002;43(13):129.
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Purpose: To evaluate the safety and efficacy of human derived fibrin glue (Beriplast P) for attaching conjunctival autografts during primary pterygium surgery. Methods: Twenty-two eyes underwent excision of primary pterygia with conjunctival autografting. Eleven eyes were randomly assigned to undergo attachment of the autograft using nylon 10-0 sutures; the other eleven eyes underwent attachment of the autograft using human derived fibrin glue (Beriplast P). Main outcome measures included graft survival, duration of surgery, subjective discomfort, and visual acuity. Results: The graft survival rate was 100% for both groups at the end of the follow up period of two months. The average duration of surgery for the fibrin glue group (27 minutes) was shorter than that of the sutured group (67 minutes) (p<0.001). Subjective symptoms of pain, foreign body sensation, and tearing were less intense and of shorter duration in the fibrin glue group on all follow up days (P<0.001). One case of prolonged subconjunctival hemorrhage occured in the fibrin glue group; one case of partial graft dehiscence occured in the sutured group. None of the patients lost vision. Conclusion: Human derived fibrin glue (Beriplast P) is an effective, efficient, and safe alternative for attaching conjunctival autografts in primary pterygium surgery.
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