December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Comparative Corneal Topography, Corneal Thickness and Refractive Variables in Monozygotic and Dizygotic Twins
Author Affiliations & Notes
  • Y-F Shih
    Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan Republic of China
  • W-L Chen
    Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan Republic of China
  • J-F Fung
    Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan Republic of China
  • F-R Hu
    Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan Republic of China
  • I-J Wang
    Department of Ophthalmology National Taiwan University Hospital Taipei Taiwan Republic of China
  • Footnotes
    Commercial Relationships   Y. Shih, None; W. Chen, None; J. Fung, None; F. Hu, None; I. Wang, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 176. doi:
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      Y-F Shih, W-L Chen, J-F Fung, F-R Hu, I-J Wang; Comparative Corneal Topography, Corneal Thickness and Refractive Variables in Monozygotic and Dizygotic Twins . Invest. Ophthalmol. Vis. Sci. 2002;43(13):176.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To investigate the role of heredity in determining corneal shape, thickness, axial length and overall refractive error. Methods: 48 mnozygotic and 39 dizygote twin pairs, age 18 to 47 years, were enrolled in the study. Refractive error was determined by an automated refractometer. Manifest refraction was also recorded, as well as cycloplegic refraction in subjects under 18 years. Anterior corneal topographic pattern was obtained with Orbscan II and TMS-I. Posterior corneal topographic pattern was obtained with Orbscan II. Corneal thickness was obtained with Orbscan II and ultrasound pachymetry. Axial lengths were determined by A-scan ultrasound. Data were analyzed by Student t test only in the right eye. Left-eye data were comparable for all variables. Results: Mean intrapair difference in refractive error (spherical equivalent) was less for monzygotic than for dizygtic twin. (RE: 0.45 vs 1.64; p=0.001). Mean intrapair difference in axial difference in axial length was less for monozygotic twin (RE: 0.24 vs 0.58 mm;P=0.001). There was no significant intrapair difference in corneal thickness (RE: 4.8µm vs 5.2 µm, P≷0.05) Anterior corneal topographic pattern data (power and meridian) in all zones (3,5,7 mm), anterior and posterior elevation map also showed small differences among monozygotic pairs than dizygotic twins. Conclusion: Corneal topography data, axial length and overall refractive error have a significant genetic basis. There was no significant genetic bases for corneal thickness.

Keywords: 543 refractive error development • 599 topography • 481 myopia 
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