December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
The Association Between OCT Measured RNFL Thinning and Standard Automated Perimetry Pattern Deviation
C Bowd; TA El Beltagi; C Boden; P Amini; PA Sample; LM Zangwill; RN Weinreb
Author Affiliations & Notes
  • C Bowd
    Glaucoma Center University of California San Diego La Jolla CA
  • TA El Beltagi
    Glaucoma Center University of California San Diego La Jolla CA
  • C Boden
    Glaucoma Center University of California San Diego La Jolla CA
  • P Amini
    Glaucoma Center University of California San Diego La Jolla CA
  • PA Sample
    Glaucoma Center University of California San Diego La Jolla CA
  • LM Zangwill
    Glaucoma Center University of California San Diego La Jolla CA
  • RN Weinreb
    Glaucoma Center University of California San Diego La Jolla CA
  • Footnotes
    Commercial Relationships   C. Bowd, None; T.A. El Beltagi, None; C. Boden, None; P. Amini, None; P.A. Sample, None; L.M. Zangwill, None; R.N. Weinreb, None. Grant Identification: NIH Grants EY11008 (LMZ) and EY08208 (PAS)
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 254. doi:
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      C Bowd, TA El Beltagi, C Boden, P Amini, PA Sample, LM Zangwill, RN Weinreb; The Association Between OCT Measured RNFL Thinning and Standard Automated Perimetry Pattern Deviation . Invest. Ophthalmol. Vis. Sci. 2002;43(13):254.

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Abstract

Abstract: : Purpose: To determine the relationship between areas of RNFL thinning identified by OCT and areas of decreased visual field sensitivity identified by standard automated perimetry (SAP) in eyes with glaucomatous optic neuropathy (GON). Methods: 43 eyes with GON identified by evaluation of optic disc stereo-photographs were included. OCT scans were obtained within 6 months of reliable SAP testing. The location and number of abnormal OCT clock hour RNFL thickness measures (thickness ≤ 97.5% of our normative database, n=99) were compared to the location and number of abnormal visual field zones (Weber and Ulrich, 1991) (SAP PD ≤ 95% of our normative database, n=348). The relationship between the deviation from normal OCT measured RNFL thickness at each clock hour and the average PD in each visual field zone also was examined. Results: RNFL thickness was most frequently abnormal in the inferior (6:00, n=13 eyes, 30%) and inferior temporal regions (7:00, 8:00, 9:00; all n=10 eyes, 23%). The three clock hour regions with mean thickness measurements most deviant from mean normal values were (mean ± S.D.) 7:00 (-33.38 ± 38.01 mm), 6:00 (-30.19 ± 37.24 mm), and 1:00 (-22.31 ± 29.48 mm). The most frequently abnormal visual field zones were in the superior hemifield (zones 14, 15, both 9 eyes, 21%; and zone 13, 7 eyes, 16%). The three least sensitive visual field zones by PD were (mean ± S.D.) zone 14 (-3.51 ± 4.05 dB), zone 15 (-3.34 ± 4.04 dB), and zone 13 (-3.16 ± 5.68 dB). Linear regression results (R2) showed that deviation from normal RNFL thickness at OCT clock hour positions 6;00, 7:00, and 8:00 was best correlated with SAP PD in the superior arcuate / nasal step region. R2 values for these associations ranged from 0.35 to 0.59. These values were approximately 70 to 100 times greater than between clock hour position 6:00 and visual field zone 8 (inferior nasal step region) (R2 = 0.005), where such a correlation is not predicted based on topographic mapping. Conclusion: Localized RNFL thinning, measured by OCT, is topographically related to decreased localized SAP sensitivity in eyes with glaucomatous optic neuropathy.

Keywords: 430 imaging/image analysis: clinical • 484 nerve fiber layer • 511 perimetry 
© 2002, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2015 Association for Research in Vision and Ophthalmology.
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