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S Den, C Sotozono, S Kinoshita, H Oku, T Ikeda; Alkali Injury Causes Inflammatory Response in the Retina, Leading to the Retinal Damage . Invest. Ophthalmol. Vis. Sci. 2002;43(13):27.
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Purpose:In sever alkali injury, alkali solution penetrates to the intraocular tissues and causes extensive ocular damage. To know retinal damage, we investigated changes in retinal function, structure and inflammatory cytokine expression after alkali injury. Methods:Central corneal alkali injuries were produced by placing filter paper discs wetted with 1N NaOH on 6 Wistar rat corneas for 1 min. Six uninjured eyes were served as controls. Changes in retinal function were evaluated 1, 2, 4 and 8 weeks after injury, using electroretinogram (ERG). Histological changes were examined 4 and 8 weeks after injury. Also, interleukin (IL)-1ß, -6 and -8 in the alkali-injured retinas were quantified using ELISA systems. Results:The amplitudes of a- and b-wave were significantly reduced 8 weeks after injury in alkali-injured eyes. Histological examination revealed massive retinal destruction and cell infiltration. IL-1ß, -6 and -8 were elevated after alkali injury which reduced to the control levels by 7 days. Conclusion: The results suggest that alkali injury to the cornea may cause inflammatory response in the retina, leading to retinal damage. For better visual prognosis after alkali injury, it may be necessary to suppress sufficiently these inflammatory reactions.
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